The Comparison of Changes of QTc, Tp-e Interval, and Tp-e/QT Ratio, Tp-e/QTc Ratio on the ECG During Living Donor Liver Transplantation Under Desflurane and Total Intravenous Anesthesia -Randomized Controlled Trial

Not Applicable

Completed

• Conditions: Liver Cirrhosis(Who Will Undergo Planed Liver Transplantation)
• Interventions: Drug: inhalation (desflurane) group; Drug: total intravenous (propofol) anesthesia

• Registration Number: NCT03864276
• Lead Sponsor: Yonsei University

Brief Summary

Prolonged corrected QT interval (QTc) has been observed in about half of patients with liver cirrhosis. Marked prolongation of QTc (ie, 500 msec) has been considered to be a risk factor for fatal ventricular arrhythmia, such as torsade de pointes,7,8 which has been reported in liver transplantation (LT) surgery. In a previous study, prolonged QTc interval ( 500 msec) was frequently observed throughout the procedure of LT, even among patients with baseline QTc 440 msec. Therefore, it is important to optimize electrolyte balance and hemodynamic status to reduce greater risk of perioperative arrhythmias.

The investigators hypothesized that the change of QTc interval might be differ according to method of general anesthesia (inhalation agent vs. intravenous agent).

Detailed Description

Not available

Study Timeline

• Study Start: 2019-02-17
• Study First Submitted: 2019-03-04
• Study First Submitted QC: 2019-03-04
• Study First Posted: 2019-03-06
• Primary Completion: 2020-12-31
• Study Completion: 2020-12-31
• Status Verified: 2021-10
• Last Update Submitted: 2021-10-14
• Last Update Posted: 2021-10-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• patients with liver cirrhosis who will undergo planned liver transplantation

Exclusion Criteria

• 1. emergent liver transplantation
• 2. unstable angina
• 3. recent MI(Myocardial Infarction)
• 4. uncontrolled hypertension (diastolic BP > 110mmHg)
• 5. implantable cardiac defibrillator
• 6. severe obesity (BMI>30kg/m2)
• 7. allergy to propofol

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
inhalation anesthesia (desflurane) group	inhalation (desflurane) group	Anesthesia is induced and maintained with desflurane and sufentanil
Total intravenous anesthesia (propofol) group	total intravenous (propofol) anesthesia	Anesthesia is induced and maintained with propofol and sufentanil

Primary Outcome Measures

Name	Time	Method
QTc interval	3 minutes after liver reperfusion	The investigator will assess the QTc interval 3 minutes after the reperfusion during liver transplantation.

Secondary Outcome Measures

Name	Time	Method
QTc interval	at the end of the surgery	The investigator will assess the QTc interval at the end of liver transplantation.

Trial Locations

Locations (1)

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine; 🇰🇷 Seoul, Korea, Republic of