Evaluation of a novel topical gel for hand osteoarthritis pain: An exploratory trial

niversity of Canberra0 个研究点目标入组 60 人开始时间: 2022年1月24日最近更新: 2022年1月31日

适应症

试验速览

暂无简介。

•1. Adults of any age over 18 years.
•2. Have been diagnosed with hand osteoarthritis
•3. Have at least two inter/distal phalangeal and/or one first carpometacarpal joint pain
•4. Have at least two or three painful flare-ups of pain in a finger joint during the previous 12 months
•5. Discontinuation of all analgesic (prescription or over the counter) at least 3 days prior to first application.
•6. Able and willing to provide informed consent

•1.Allergies to NSAIDs or any of either of the gel’s ingredients
•2.Inflamed or broken skin in area to be treated
•3.Signs or symptoms of systemic infection (such as fever, and chills, nausea and vomiting, blotchy or discoloured skin, weakness, or diarrhoea) as this is not indicated for local osteoarthritis pain
•4.Systemic conditions (i.e. rheumatoid arthritis, Buerger’s disease, mucous cyst, dactylitis, pyogenic granuloma) and/or taking anti-rheumatic drugs (i.e. methotrexate, cyclosporine)
•5.Autoimmune diseases: lupus, multiple sclerosis
•6.Have chronic kidney disease/acute kidney injury
•7.Use of non-prescription topical or oral analgesic treatment within the last 48 hours
•8.Current use of a prescription topical or oral analgesic treatment and unable to stop this for the duration of the trial
•9. History of stomach ulcers
•10. Asthma
•11. Anticoagulation/antithrombotic therapies such as aspirin and warfarin
•12. Antidepressant therapies such as Sertraline (Zoloft), citalopram, fluoxetine and paroxetine
•13. Taking blood pressure medications
•14. Acute injury or trauma to either hand in the previous 2 months
•15. Anyone with loss of sensation in their hands
•16. Pregnancy
•17. Scheduled surgery within 2 weeks as there may be a low risk for post-operative bleeding.

发起方

niversity of Canberra