"Predicting Glaucoma Progression With Optical Coherence Tomography Structural and Angiographic Parameters".

Brief Summary

Detailed Description

Subjects will go a comprehensive ophthalmologic examination including review of medical history, best-corrected visual acuity (BCVA), slit-lamp biomicroscopy, intraocular pressure (IOP) measurement, gonioscopy, dilated fundoscopic examination, stereoscopic optic disc photography, and automated perimetry using Swedish Interactive Threshold Algorithm (SITA Standard 24-2). Only subjects with open angles on gonioscopy were included. One eye of each subject will be scanned by a high-speed 1050-nm-wavelength swept-source OCT instrument. OCT is providing measurements of the RNFL thickness, ONH, as well as the inner macula for the assessment of glaucoma progression. The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm will be used to compute 3-dimensional optic disc angiography. A disc flow index was computed from 4 registered scans. Evaluation of progressive changes of the optic disc and RNFL will be based on event-analysis and/or trend-analysis. In event analysis, progression is defined when the difference between the baseline and follow-up measurements of the parameter of interest is greater than its test-retest variability (or the reproducibility coefficient). In trend analysis, regression analysis is performed between the parameter of interest and time.

Primary Outcomes

Secondary Outcomes

• disc perfusion changes(one year)