Cardiovascular and Respiratory Assessment Using Biometric Signals in a Non-contact Monitoring Device
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- End-stage Renal Disease
- Sponsor
- Lawson Health Research Institute
- Enrollment
- 14
- Locations
- 1
- Primary Endpoint
- Mobile CVInsight validation against the CVInsight contact device by recording oxygen saturation variability
- Status
- Terminated
- Last Updated
- 4 years ago
Overview
Brief Summary
Patients on hemodialysis treatment experience increased levels of cardiovascular disease. In this study, investigators will be detecting hemodialysis induced circulatory stress using the CVInsight Patient Monitoring & Informatics System - InteloMed. This system consists of the CVInsight non-contact device and the CVInsight contact device that measures a patient's response to dialysis by looking at many physiological parameters such as heart rate, heart rate variability, respiratory rate, and how much oxygen the blood is carrying. Investigators would like to validate the mobile CVInsight non-contact device to the currently used standard CVInsight contact device to provide healthcare providers with a better understanding of its role in early detection of cardiovascular stress induced by hemodialysis.
Detailed Description
This observational validation trial involves patients from the prevalent dialysis population in London, Ontario. Investigators intend to validate the mobile CVInsight non-contact device to the standard contact version of this device for assessing hemodialysis induced circulatory stress. The CVInsight Patient Monitoring \& Informatics System records a patient's pulse waveform to determine a patient's response to dialysis and alerts to several physiologic changes including pulse strength, pulse rate, pulse irregularity, oxygen saturation, and oxygen saturation variability. The CVInsight contact and non-contact devices will be used for two study visits. The first study visit will be on the patient's first dialysis session of the week (after the weekend - 72 hour inter-dialytic period) and the second study visit will be during the patient's second dialysis session of the week (mid week - 48 hour inter-dialytic period). This will allow investigators to see if there is a difference between these two intervals of time. The investigators will also be using other gold standard methods of validating components of this device including myocardial stunning using the GE Healthcare Vivid q cardiovascular ultrasound system. The echocardiographic ultrasound machine and finometer will be used for two study visits to take place during the patients' regularly scheduled dialysis sessions. The first echocardiogram will be done prior to the initiation of dialysis and the second at peak dialysis stress, which is 15 minutes before the end of the hemodialysis treatment. In addition, the finometer will be used continuously throughout hemodialysis.Validating the mobile CVInsight non-contact device to the CVInsight contact device will allow investigators to observe the degree to which these devices are able to detect hemodialysis induced circulatory stress, which will enable the healthcare provider to detect injury early enough to intervene prior to its occurrence. This is important because hemodialysis and the accompanying stress it induces increases mortality significantly in this population of patients. This study is investigator initiated and the study will continue until the investigators reach our target sample size. Each patient will have two study visits. Patients on a Monday, Wednesday, and Friday schedule will have study visits on Monday and Wednesday of the same week and patients on a Tuesday, Thursday, and Saturday schedule will have study visits on Tuesday and Thursday of the same week.
Investigators
Chris McIntyre
Professor of Medicine, Medical Biophysics and Paediatrics, Robert Lindsay Chair of Dialysis Research and Innovation
Lawson Health Research Institute
Eligibility Criteria
Inclusion Criteria
- •Patients receiving conventional thrice weekly maintenance HD
- •Age ≥18 years
- •Able to provide informed consent
Exclusion Criteria
- •Not meeting inclusion criteria
Outcomes
Primary Outcomes
Mobile CVInsight validation against the CVInsight contact device by recording oxygen saturation variability
Time Frame: Through dialysis session, an average of 4 hours for two separate visits within the same week.
Validation of the mobile CVInsight with the oxygen saturation variability (derived from the oximeter signal) from the CVInsight contact device
Mobile CVInsight validation against the CVInsight contact device by recording pulse strength
Time Frame: Through dialysis session, an average of 4 hours for two separate visits within the same week.
Validation of the mobile CVInsight with pulse strength (derived from a photoelectric plethysmograph waveform) from the CVInsight contact device
Mobile CVInsight validation against the CVInsight contact device by recording oxygen saturation
Time Frame: Through dialysis session, an average of 4 hours for two separate visits within the same week.
Validation of the mobile CVInsight with the percentage of oxygen carried in blood from the CVInsight contact device
Mobile CVInsight validation against the CVInsight contact device by recording pulse irregularity
Time Frame: Through dialysis session, an average of 4 hours for two separate visits within the same week.
Validation of the mobile CVInsight with pulse irregularity (derived from the pulse wave signal) from the CVInsight contact device
Mobile CVInsight validation against the CVInsight contact device by recording pulse rate trends
Time Frame: Through dialysis session, an average of 4 hours for two separate visits within the same week.
Validation of the mobile CVInsight with pulse rate from the CVInsight contact device
Secondary Outcomes
- Early detection of hemodialysis-induced circulatory stress using the CVInsight System(Through dialysis session, an average of 4 hours for two separate visits within the same week.)
- Early detection of hemodialysis-induced circulatory stress using the finometer(Through dialysis session, an average of 4 hours for two separate visits within the same week.)
- Early detection of hemodialysis-induced circulatory stress using echocardiography(Before the dialysis session and 15 minutes prior to the end of the dialysis session for two separate visits within the same week.)