Surgical excision versus Mohs*micrographic surgery for cutaneous Squamous Cell Carcinoma
- Conditions
- skincancerSquamous cell carcinoma10040900
- Registration Number
- NL-OMON36835
- Lead Sponsor
- Catharina-ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Histologically confirmed cutaneous squamous cell carcinoma T1, stage 1, without high-risk characteristics. Squamous cell carcinoma at sun-exposed sides excluding lip and ear, tumour smaller than 20mm in diameter, tumours smaller than 4mm in dept and confined to the dermis, histologically well to moderately differentiated or verrucous subtype and without evidence of immune dysfunction.
Squamous cell carcinoma >= TNM II of the ear, lip and non-exposed sites (e.g. perineum, sacrum, sole of foot), arising in areas of radiation, chronic ulcers, tumours greater than 20mm in diameter, tumours greater 4mm in dept or extending down to the subcutaneous tissue, poorly differentiated, perineural involvement, acantolytic, incomplete excision, desmoplastic characteristics, angio-involvement, recurrent tumours, positive lymph nodes, immunosuppressive therapy (e.g. after organ transplantation), chronic immunosuppressive disease. Bowen*s disease, mucosal squamous cell carcinoma and actinic keratosis.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The effectiveness of Mohs' micrographic surgery compared to surgical excision<br /><br>is measured according to three primary outcome measures: 1. Throughput time, 2.<br /><br>Quality of life and 3. Patient satisfaction.<br /><br>The throughput time is the time from the first contact at the out patient<br /><br>clinic untill the end of the treatment.</p><br>
- Secondary Outcome Measures
Name Time Method <p>As a secondary outcome we will study recurrence rate and costs of both<br /><br>treatments.</p><br>