Comparison of fractionated dose versus bolus dose injection in spinal anaesthesia for patients undergoing elective caesarean section
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- To compare the hemodynamic stability in fractionated dose versus bolus dose in spinal Anaesthesia for patients undergoing elective lower segment caesarean section (LSCS).
研究概览
简要总结
Spinal anesthesia has a rapid onset but at the same time, it
precipitates hypotension. The incidence of hypotension is reported to
be 92%–94% when no preventive measures are taken. Bolus dose of the local anesthetic agent in Spinal anesthesia causes more hypotension. The fractionated dose of the local
anesthetic agent, in which two-third of the total calculated dose given initially followed by one-third
dose after a time gap of 90 s, achieves adequate spinal anesthesia and provides a dense block with
hemodynamic stability
The study will be used to compare the hemodynamic stability, duration of analgesia and the characteristics of sensory and motor blockade in fractionated dose versus bolus
dose in spinal Anesthesia for patients undergoing elective lower segment caesarean section.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- Female
入选标准
- •American Society of Anesthesiologists physical status I and II, age from 18 to 40 years, height from 150 to 170 cm, pregnancies scheduled for elective Lower Segment Caesarean Section under Spinal anaesthesia.
排除标准
- •Pre-existing diseases Pregnancy-induced hypertension Cardiovascular disease Cerebrovascular disease Any contraindication to Spinal anaesthesia Weight less than 50 kg or more than 110 kg Height less than 150 cm Severely altered mental status Spine deformities History of laminectomy.
结局指标
主要结局
To compare the hemodynamic stability in fractionated dose versus bolus dose in spinal Anaesthesia for patients undergoing elective lower segment caesarean section (LSCS).
时间窗: First 6 hours
次要结局
- To compare duration of analgesia and to compare the sensory and motor block characteristics
研究者
venkat Prabu P
Chettinad Hospital and Research Insitute