Aflibercept as Adjunctive Treatment for Filtration Surgery in Neovascular Glaucoma

Not Applicable

Completed

• Conditions: Glaucoma Secondary to Eye Inflammation; Neovascular Glaucoma; Vascular Endothelial Growth Factor Overexpression; Intraocular Pressure

• Registration Number: NCT04970251
• Lead Sponsor: Siriraj Hospital

Brief Summary

Purpose: To investigate intravitreal aflibercept (IVA) injection as an adjunctive treatment to trabeculectomy with mitomycin C (TMC) and panretinal photocoagulation (PRP) for neovascular glaucoma (NVG).

Setting: Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand Study design: Prospective interventional case series Methods: PRP and IVA (2 mg/0.05 ml) injection were given, and TMC was performed within 2 weeks after IVA. Additional PRP, laser suture lysis, subconjunctival 5-fluorouracil injection, and bleb needling were performed after TMC if indicated. Best-collected visual acuity (BCVA), intraocular pressure (IOP), surgical complications, and number of anti-glaucoma medications were collected.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-11-01
• Primary Completion: 2021-03-31
• Study Completion: 2021-03-31
• Study First Submitted: 2021-06-24
• Status Verified: 2021-07
• Study First Submitted QC: 2021-07-11
• Last Update Submitted: 2021-07-11
• Study First Posted: 2021-07-21
• Last Update Posted: 2021-07-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 5

Inclusion Criteria

• Consecutive patients with neovascular glaucoma who presented at the Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand during November 2018 to October 2019.
• Aged more than 18 year-old

Exclusion Criteria

• Patients who received any anti-vascular endothelial growth factor treatment before participation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Intraocular pressure	Post-operative on month 36th	Intraocular pressure after trabeculectomy

Secondary Outcome Measures

Name	Time	Method
Visual acuity	Post-operative on month 36th	Visual acuity of the studied eye
Numbers of medication	Post-operative on month 36th	Numbers of anti-glaucoma medications

Trial Locations

Locations (1)

Naris Kitnarong; 🇹🇭 Bangkoknoi, Bangkok, Thailand