Double sequential external defibrillation in refractory ventricular fibrillation - the DOSEVF2 trial, a prospective cluster randomised study
Not Applicable
- Conditions
- I46.0Cardiac arrest with successful resuscitation
- Registration Number
- DRKS00032830
- Lead Sponsor
- niversitätsklinikum Heidelberg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 752
Inclusion Criteria
Out of hospital cardiac arrest
VF or pVT or shockable rhythm” determined by an AED
Refractory VF/pVT defined as persistent VF/pVT after three defibrillations
First dose of amiodarone (300mg) or lidocaine (100mg) according to current ERC guidelines
Exclusion Criteria
DNR/DNI
Recurrent cardiac arrest with any-ROSC before 4th shock
Stacked Defibrillation
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Hierarchical testing<br>(1)Successful termination of VF / pVT<br>(2)Survival at 24 hours<br>(3)Survival at 30 days with good neurological outcome (CPC 1-2)
- Secondary Outcome Measures
Name Time Method CPC 1-2 or mRS =2 at hospital discharge<br>ROSC at hospital admission<br>Overall survival at hospital discharge<br>Overall survival at day 30<br>Differences in survival between study phases within each cluster<br>Any ROSC during prehospital phase<br>Differences in Joules used<br>Differences in impedance <br>Differences in survival between study sites