Bedside Tests of Cardiorespiratory Fitness

Completed

• Conditions: Aging

• Registration Number: NCT06062784
• Lead Sponsor: University of Nottingham

Brief Summary

A study of 64 older adults over the age of 65y to assess the utility of patient characteristics and bedside measures of physical function and muscle size to predict cardiorespiratory fitness.

Detailed Description

A study of 64 older adults over the age of 65y to assess the utility of patient characteristics (age, gender and BMI) and bedside measures of physical function (handgrip strength and step box test) and muscle size (muscle thickness via B-mode ultrasonography (US)) to predict cardiorespiratory fitness (VO2peak and anaerobic threshold) as measured by the gold-standard assessment method, cardiopulmonary exercise testing (CPET).

Each participant will take part in a single assessment day (after health screening against CPET safety criteria) whereby they will have US measures of the vastus lateralis before completing HGS and step box test assessments, and finally a CPET.

Study Timeline

• Study Start: 2019-01-01
• Primary Completion: 2021-12-31
• Study Completion: 2021-12-31
• Status Verified: 2023-09
• Study First Submitted: 2023-09-07
• Study First Submitted QC: 2023-09-21
• Last Update Submitted: 2023-09-21
• Study First Posted: 2023-10-02
• Last Update Posted: 2023-10-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

• Over 65y
• Independent, community-dwelling

Exclusion Criteria

• Contraindications to CPET safety criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cardiorespiratory fitness (CRF) - VO2 max	Single time-point - 8 to 12 minutes	CRF via cardiopulmonary exercise testing (CPET). This includes a measure of maximum oxygen uptake (VO2 max) determined via inline breath gas analysis during an incremental cycle test.
Cardiorespiratory fitness (CRF) - Anaerobic threshold	Single time-point - 8 to 12 minutes	CRF via cardiopulmonary exercise testing (CPET). This includes a measure of anaerobic threshold (AT) determined via inline breath gas analysis during an incremental cycle test.

Secondary Outcome Measures

Name	Time	Method
Muscle architecture - pennation angle	Single time-point: 10 minutes	Analysis of vastus lateralis pennation angle using b-mode ultrasonography
Muscle architecture - muscle thickness	Single time-point: 10 minutes	Analysis of vastus lateralis muscle thickness using b-mode ultrasonography
Muscle architecture - fascicle length	Single time-point: 10 minutes	Analysis of vastus lateralis fascicle length using b-mode ultrasonography

Trial Locations

Locations (1)

Centre of Metabolism, Ageing and Physiology (COMAP), University of Nottingham; 🇬🇧 Derby, Derbyshire, United Kingdom