Exploring the Utility of Bedside Tests for Predicting Cardiorespiratory Fitness in Older Adults
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Aging
- Sponsor
- University of Nottingham
- Enrollment
- 64
- Locations
- 1
- Primary Endpoint
- Cardiorespiratory fitness (CRF) - VO2 max
- Status
- Completed
- Last Updated
- 8 months ago
Overview
Brief Summary
A study of 64 older adults over the age of 65y to assess the utility of patient characteristics and bedside measures of physical function and muscle size to predict cardiorespiratory fitness.
Detailed Description
A study of 64 older adults over the age of 65y to assess the utility of patient characteristics (age, gender and BMI) and bedside measures of physical function (handgrip strength (HGS) and step box test) and muscle size (muscle thickness via B-mode ultrasonography (US)) to predict cardiorespiratory fitness (VO2peak and anaerobic threshold) as measured by the gold-standard assessment method, cardiopulmonary exercise testing (CPET). Each participant will take part in a single assessment day (after health screening against CPET safety criteria) whereby they will have US measures of the vastus lateralis before completing HGS and step box test assessments, and finally a CPET.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Independent, community-dwelling
Exclusion Criteria
- •Contraindications to CPET safety criteria
Outcomes
Primary Outcomes
Cardiorespiratory fitness (CRF) - VO2 max
Time Frame: Single time-point - 8 to 12 minutes
CRF via cardiopulmonary exercise testing (CPET). This includes a measure of maximum oxygen uptake (VO2 max) determined via inline breath gas analysis during an incremental cycle test.
Cardiorespiratory fitness (CRF) - Anaerobic threshold
Time Frame: Single time-point - 8 to 12 minutes
CRF via cardiopulmonary exercise testing (CPET). This includes a measure of anaerobic threshold (AT) determined via inline breath gas analysis during an incremental cycle test.
Secondary Outcomes
- Muscle architecture - pennation angle(Single time-point: 10 minutes)
- Muscle architecture - muscle thickness(Single time-point: 10 minutes)
- Muscle architecture - fascicle length(Single time-point: 10 minutes)