Botulinum Toxin and Mesotherapy on Enhancement of Facial Scarring
- Conditions
- Facial Scars
- Registration Number
- NCT06562023
- Lead Sponsor
- Hams Hamed Abdelrahman
- Brief Summary
Most of the body's tissues can undergo wound repair following a disruption of tissue integrity. Upon healing, these wounds result in scar formation. The scars widen when the overlying musculature pulls apart suture lines. Botulinum Toxin A (BTA) is known to prevent fibroblast proliferation and it also induces temporary muscle paralysis. Also, mesotherapy is the non-invasive transdermal injection which can aid the skin to increase collagen and elastin production. Thus, both techniques are eligible for enhancement of facial scars.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 33
- Patient suffering from vertical or oblique forehead lacerations caused by trauma.
- Recent and fresh wounds.
- Atrophic scar (linear scar).
- Infected wound.
- Patient on chemotherapy treatment and history of malignancy.
- Patients suffering from burns on the forehead or complicated lacerations.
- Allergy to drugs used in this study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Change in scar appearance Baseline, 1 month, 3 months, 6 months The Vancouver Scar Scale (VSS) will be measured to calculate scar appearance. The VSS evaluates four indicators: vascularity, pigmentation, pliability, and height. It has a score ranging from 0-13.
* Vascularity: Normal 0, Pink 1, Red 2, Purple 3
* Pigmentation: Normal 0, Hypopigmentation 1, Hyperpigmentation 2
* Pliability: Normal 0, Supple 1, Yielding 2, Firm 3, Ropes 4, Contracture 5
* Height: Flat (0), \< 2 mm (1), 2-5 mm (2), \> 5 mm (3)Change in wound width Baseline, 1 month, 3 months, 6 months The mean wound width will be measured using a graduated Vernier caliper
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Outpatient Clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University
🇪🇬Alexandria, Egypt
Outpatient Clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University🇪🇬Alexandria, Egypt