The Perioperative Value of Platelet Counts in Predicting Outcome After Liver Transplantation
试验速览
- 阶段
- 不适用
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- Severe complication after liver transplantation
研究概览
简要总结
Recent experimental and clinical studies have shown that platelets play a critical role in liver ischemia and regeneration. Thrombocytopenia, a frequent and potentially serious condition in liver transplantation (LT) recipients, was shown to be associated with postoperative morbidity and mortality after partial hepatectomy.
The investigators aim at evaluating whether postoperative low platelet counts are indicators of short- and long-term outcomes after liver transplantation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age >18 years old
- •End stage liver disease
- •Cadaveric-donor liver transplantation
排除标准
- •Age <18 years old
- •Pregnancy
- •Living-related liver transplantation
结局指标
主要结局
Severe complication after liver transplantation
时间窗: 90 days
The severity of complications will be graded according to the Clavien-Dindo classification by outcome. Grade III to V complications will be considered as severe.
次要结局
- Delayed graft function(7 days after liver transplantation)
- Primary graft non-function(first postoperative week)
研究者
Dimitri Aristotle Raptis
MD, PhD
University of Zurich