The Perioperative Value of Platelet Counts in Predicting Outcome After Liver Transplantation

• Conditions: Death; Complication
• Interventions: Procedure: Liver transplantation

• Registration Number: NCT01711957
• Lead Sponsor: University of Zurich

Brief Summary

Recent experimental and clinical studies have shown that platelets play a critical role in liver ischemia and regeneration. Thrombocytopenia, a frequent and potentially serious condition in liver transplantation (LT) recipients, was shown to be associated with postoperative morbidity and mortality after partial hepatectomy.

The investigators aim at evaluating whether postoperative low platelet counts are indicators of short- and long-term outcomes after liver transplantation.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2008-01
• Status Verified: 2012-10
• Study First Submitted: 2012-10-18
• Study First Submitted QC: 2012-10-22
• Study First Posted: 2012-10-23
• Last Update Submitted: 2012-10-23
• Last Update Posted: 2012-10-24
• Primary Completion: 2013-01
• Study Completion: 2013-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

• Age >18 years old
• End stage liver disease
• Cadaveric-donor liver transplantation

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Exclusion Criteria

• Age <18 years old
• Pregnancy
• Living-related liver transplantation

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Liver disease and liver transplantation	Liver transplantation	Patient with end stage liver disease and/or primary liver tumor undergoing liver transplantation

Primary Outcome Measures

Name	Time	Method
Severe complication after liver transplantation	90 days	The severity of complications will be graded according to the Clavien-Dindo classification by outcome. Grade III to V complications will be considered as severe.

Secondary Outcome Measures

Name	Time	Method
Delayed graft function	7 days after liver transplantation	Defined as the presence of at least one of the following parameter at 7 days after LT: serum bilirubin \> 10 mg/dL and International Normalized Ratio (INR) \>1.6 or Alanine aminotransferase serum level (ALT) \>2000UI/L
Primary graft non-function	first postoperative week	Defined as death or retransplantation within the first postoperative week after exclusion of technical, immunological, and infectious causes

Trial Locations

Locations (1)

University Hospital Zurich, Department of Visceral Surgery and Transplantation; 🇨🇭 Zurich, Switzerland