Automatic detection and analysis of glaucoma disease through Intraocular pressure (IOP), Fundus and Optical coherence tomography (OCT) images.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Retinal Nerve Fiber Layer Thickness calculated from OCT images using proposed approach is used for early detection of glaucoma
研究概览
简要总结
purpose and background of trial: Glaucoma is a multi-factorial optic neuropathy characterised by progressive structural loss of retinal ganglion cells (RGC) that may result in vision loss and irreversible blindness. The ability to detect structural loss is fundamental in the diagnosis and management of glaucoma. While glaucomatous structural damage can be assessed subjectively by clinically examining the optic nerve head (ONH),IOP and peripapillary retinal nerve fibre layer (RNFL), the introduction of ocular imaging modalities into clinical management has allowed for supplemental objective and quantitative evaluation of ocular structure.so, this study is helpful for analysis of glaucoma disease in the initial stage.
findings of study:
- A approach to measure the thickness of retinal nerve fiber layer from OCT images
- Aapproach to extract cup and disc areas from fundus images and calculate the cup to disc ratio.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Aged between 18 to 70 years
- •Data will be collected from the records of patients who have undergone comprehensive eye checkup including IOP, disc photograph and OCT RNFL.
- •No history of eye disease
- •No history of diabetes mellitus.
排除标准
- •Aged under 18 or over 70 years
- •Chemical injury eye, infected eye, eye with blocked blood vessels, and eye affected by inflammatory conditions
- •Patients have diabetic retinopathy.
结局指标
主要结局
Retinal Nerve Fiber Layer Thickness calculated from OCT images using proposed approach is used for early detection of glaucoma
时间窗: 4 months
次要结局
- Cup to Disc ratio calculated from fundus images using proposed approach is used for early detection of glaucoma(4 months)