Prolonged repetitive nerve stimulation (RNS) in myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS): quantitative and relevant.
- Conditions
- myasthenia MG LEMS10029317
- Registration Number
- NL-OMON31264
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
over 18 years old
MG: clinical signs and symptoms of MG, positive for anti-AChR antibodies and characteristic RNS EMG abnormalities (decrement over 10%) or abnormal Single Fibre EMG.
LEMS: clinical signs and symptoms of LEMS, positive for anti-VGCC antibodies and characteristic RNS EMG abnormalities (decrement over 10% and increment over 60%) or abnormal Single Fibre EMG.
Exclusion Criteria
anticoagulant drugs
muscle and nerve diseases or diseases predisposing to nerve or muscled isease, for example diabetes mellitus
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>CMAP-amplitude and change of amplitude after prolonged stimulating and<br /><br>recording. Is hte pattern different between controls itselves and between<br /><br>controls and patients?</p><br>
- Secondary Outcome Measures
Name Time Method <p>Is the technique painless indeed?</p><br>