Comparing the safety and effectiveness of plasma rich fibrin (PRF) to plasma rich platelet (PRP) in the treatment of periorbital rejuvenation and hyperpigmentatio

Not Applicable

Recruiting

• Conditions: Dark circles and wrinkles under the eyes.; Chloasma of eyelid and periocular area; H02.71

• Registration Number: IRCT20200127046282N51
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 22 July 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

Age 18-60
Darkness and wrinkles in the lower eyelid area
Informed consent

Exclusion Criteria

Patients with malignancy
Receiving chemotherapy in the past 5 years
Patients with sepsis
Smoking
Pregnancy or breastfeeding
Active wound or infection at the treatment site
Receiving any topical or systemic medication in the past 3 months for under-eye darkness

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparing the safety and effectiveness of plasma rich fibrin (PRF) to plasma rich platelet (PRP) in the treatment of periorbital rejuvenation and hyperpigmentation. Timepoint: In the study investigating the safety and efficacy of injecting fibrin-rich plasma (PRF) in treating aging and dark circles under the eyes compared to platelet-rich plasma (PRP), the time points for measuring dark circles and wrinkles are at 0, 3, 4, and 6 months after the start of the intervention. Method of measurement: In the study investigating the safety and efficacy of injecting fibrin-rich plasma (PRF) in treating aging and dark circles under the eyes compared to platelet-rich plasma (PRP), the measurement of outcome variables will be done through patient and physician satisfaction questionnaires, as well as through visioface biometric assessments.

Secondary Outcome Measures

Name	Time	Method
Satisfaction rate. Timepoint: Three months after the last meeting. Method of measurement: Comparing the severity of periorbital dark circles, before and after treatment (score from 0 - 10).