Urinary Tract Infection In Assiut University Children Hospital
- Conditions
- Urinary Tract Infections in Children
- Registration Number
- NCT06625554
- Lead Sponsor
- Assiut University
- Brief Summary
Antibiotic Sensitivity Pattern and Demographic Characteristics of Urinary Tract Infection In Assiut University Children Hospital
- Detailed Description
Urinary tract infection is the third most common serious bacterial infection in childhood and has been identified as an important risk factor for the development of progressive renal impairment and longterm consequences.
The epidemiology of UTI during childhood varies by age, gender, circumcision status, and other factors. Boys are more susceptible during the first year of life, mostly in the first 3 months, among boys, uncircumcised infants have an eightfold higher risk; due to phimosis, limiteUrinary tract infection is the third most common serious bacterial infection in childhood and has been identified as an important risk factor for the development of progressive renal impairment and longterm consequences.
The epidemiology of UTI during childhood varies by age, gender, circumcision status, and other factors. Boys are more susceptible during the first year of life, mostly in the first 3 months, among boys, uncircumcised infants have an eightfold higher risk; due to phimosis, limited retraction of the foreskin is significantly associated with an increase in UTIs in male infants, afterward, the incidence is mainly higher in girls, due to differences in anatomy .About 5% of girls and 2% of boys experience at least one incident of UTI up to the age of 7 years.
Symptoms of UTI may be minimal and non-specific in infants and small children. Febrile children not suspected of having UTI are as likely to have UTI as those who are suspected of having UTI. Therefore, diagnosis of UTI can not be made on symptomatology alone and urine examination is advocated in children with minimal suspicion of UTI.
Etiological agents of UTI are variable and usually depend on time, geographical location and age of patients. However, Escherichia coli, Proteus mirabilis, Enterobacter agglomerans, Citrobacter frreundii and Klebsiella pneumonia account for over 70% of cases.
According to sex and age, the incidence and clinical symptoms vary, and the causative organisms are different in pediatric UTI. In addition, as antibiotic-resistant pathogens change and are increased due to the abuse of antibiotics and inappropriate selection, it is necessary to select proper antibiotics in the early phase of treatment. Thus, regular antibiotic sensitivity results from the evaluation of UTI are important to improve the effectiveness of treatment.
The gold standard for the diagnosis of UTI is the detection of the pathogen in urine. The pathogen is detected and identified in urine which contributes to antibacterial treatment. Rapid administrations of empirical antibiotics are required before urine culture testing. Meanwhile, complicated UTI often increase the prevalence of inappropriate antibacterial treatment, which in turn increases antibiotic resistance ABR. In pediatric UTI, ABR is also being raised as a clinical challenge. Therefore, there is an urgent need to identify which bacterial strains in children and explore their susceptibility to commonly used antimicrobials. It could guide effective antibacterial therapy and reduce the multi-drug resistance prevalence in children.
In our study we will collect the age, sex, clinical characteristics for children, microorganism isolation and antimicrobial susceptibility profile in children who had been diagnosed with UTI.
According to sex and age, the incidence and clinical symptoms vary, and the causative organisms are different in pediatric UTI. In addition, as antibiotic-resistant pathogens change and are increased due to the abuse of antibiotics and inappropriate selection, it is necessary to select proper antibiotics in the early phase of treatment. Thus, regular antibiotic sensitivity results from the evaluation of UTI are important to improve the effectiveness of treatment.
The gold standard for the diagnosis of UTI is the detection of the pathogen in urine. The pathogen is detected and identified in urine which contributes to antibacterial treatment. Rapid administrations of empirical antibiotics are required before urine culture testing. Meanwhile, complicated UTI often increase the prevalence of inappropriate antibacterial treatment, which in turn increases antibiotic resistance ABR. In pediatric UTI, ABR is also being raised as a clinical challenge. Therefore, there is an urgent need to identify which bacterial strains in children and explore their susceptibility to commonly used antimicrobials. It could guide effective antibacterial therapy and reduce the multi-drug resistance prevalence in children.
In our study we will collect the age, sex, clinical characteristics for children, microorganism isolation and antimicrobial susceptibility profile in children who had been diagnosed with UTI.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 75
- 1-Children over 1 month and less than 18 year of age. 2-Diagnosed cases of Urinary Tract Infection. 3-who accepted to participate in the study.
- 1-neonates and patients more than 18 year. 2-children with chronic kidney diseases. 3-who refused to participate in our study.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Sample size Baseline 75 patient
The sample size was calculated using Epi-info version 7 software, based on the following assumptions:
Main outcome variable is to assess Antibiotic Sensitivity Pattern and Demographic Characteristics of Urinary Tract Infection in Children of Assiut University Hospital Based on previous studies (7) the prevalence of antibiotic resistance in children with UTI was 13%, and based on the percentage confidence limits of 5% and a Confidence level=80%Investigations Baseline 1_urine analysis 2- complete blood count(CBC) 3- urine culture and sensitivity
History Baseline 1. fever
2. burning micturation
3. dysuria
4. urgency
- Secondary Outcome Measures
Name Time Method