Postural change in hemodynamics can indicate the renal functional reserve
Phase 2
Recruiting
- Conditions
- Chronic kidney disease(CKD)
- Registration Number
- JPRN-UMIN000014035
- Lead Sponsor
- Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences
- Brief Summary
start up meeting held Five subjects were enrolled.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Not provided
Exclusion Criteria
1. previous treatment with ARB or diuretics 2 months before enrollment 2. presence or possibility of pregnancy 3. HbA1c >9.0 % 4. GOT >100, or GPT >85 5. endocrine hypertension 6. accelerated or malignant hypertension 7. serious conditions with congestive heart failure, coronary diseases, arrhythmia or systemic diseases 8. nephrotic syndrome (serum albumin <2.5 g/dl) 9. patients receiving hemodialysis therapy 10. any reason for ineligibility suggested by the attending doctor
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Relationship between the changes in resistive index in renal arteriole and natriuresis during the postural change from supine to the upright position.
- Secondary Outcome Measures
Name Time Method Relationship between the POSTURAL changes in resistive index in renal arteriole and circadian BP rhythm and urinary excretion of angiotensinogen, as well as GFR