Evaluation Of Biomarkers Associated With Bone Metabolism İn Patients With Different Periodontal Status
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Evaluation of bone metabolism biomarkers in different periodontal conditions
研究概览
简要总结
This study evaluates the levels of biomarkers associated with bone metabolism in patients with different periodontal conditions.
详细描述
Background: In this study, the levels of bone metabolism markers found in the saliva of individuals with different periodontal conditions were compared and the relationship of these markers with periodontal status was examined.
Method: A total of 60 individuals, 20 with periodontitis (P), 20 with gingivitis (G), and 20 with periodontal healthy (S), were included in the study. Periodontal clinical parameters (plaque index, gingival index, bleeding on probing, clinical attachment level and probing pocket depth) and saliva samples were obtained from the individuals. Bone metabolism biomarker (necrotizing factor (TNF)-α, osteoprotegerin (OPG), nuclear factor kappa-β receptor activator ligand (RANKL) and sclerostin) levels in saliva samples were evaluated by enzyme-linked immunosorbent assay (ELISA).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-65 years old.
- •not having any systemic disease that may affect periodontal status
- •not smoking and alcohol use
- •volunteer to participate in the study
排除标准
- •periapical pathologies;
- •resulting from orthodontics and occlusion extreme forces, including mechanical forces;
- •chronic high-dose steroid therapy;
- •radiation or immunosuppressive therapy;
- •pregnancy;
- •breastfeeding;
- •allergy or sensitivity to any medication.
- •Periodontal therapy or drug therapy for at least 6 months of study participants
结局指标
主要结局
Evaluation of bone metabolism biomarkers in different periodontal conditions
时间窗: baseline
The levels of bone metabolism markers in the saliva of individuals with different periodontal status were compared and the relationship of these markers with periodontal status was examined.
次要结局
- Probing pocket depth(baseline)
- Plaque index(baseline)
- Gingival index(baseline)
研究者
Ummuhan Tekin Atay
master in science
Necmettin Erbakan University