Evaluation Of Biomarkers Associated With Bone Metabolism İn Patients With Different Periodontal Status
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Periodontal Diseases
- Sponsor
- Necmettin Erbakan University
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Evaluation of bone metabolism biomarkers in different periodontal conditions
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
This study evaluates the levels of biomarkers associated with bone metabolism in patients with different periodontal conditions.
Detailed Description
Background: In this study, the levels of bone metabolism markers found in the saliva of individuals with different periodontal conditions were compared and the relationship of these markers with periodontal status was examined. Method: A total of 60 individuals, 20 with periodontitis (P), 20 with gingivitis (G), and 20 with periodontal healthy (S), were included in the study. Periodontal clinical parameters (plaque index, gingival index, bleeding on probing, clinical attachment level and probing pocket depth) and saliva samples were obtained from the individuals. Bone metabolism biomarker (necrotizing factor (TNF)-α, osteoprotegerin (OPG), nuclear factor kappa-β receptor activator ligand (RANKL) and sclerostin) levels in saliva samples were evaluated by enzyme-linked immunosorbent assay (ELISA).
Investigators
Ummuhan Tekin Atay
master in science
Necmettin Erbakan University
Eligibility Criteria
Inclusion Criteria
- •18-65 years old.
- •not having any systemic disease that may affect periodontal status
- •not smoking and alcohol use
- •volunteer to participate in the study
Exclusion Criteria
- •periapical pathologies;
- •resulting from orthodontics and occlusion extreme forces, including mechanical forces;
- •chronic high-dose steroid therapy;
- •radiation or immunosuppressive therapy;
- •pregnancy;
- •breastfeeding;
- •allergy or sensitivity to any medication.
- •Periodontal therapy or drug therapy for at least 6 months of study participants
Outcomes
Primary Outcomes
Evaluation of bone metabolism biomarkers in different periodontal conditions
Time Frame: baseline
The levels of bone metabolism markers in the saliva of individuals with different periodontal status were compared and the relationship of these markers with periodontal status was examined.
Secondary Outcomes
- Probing pocket depth(baseline)
- Plaque index(baseline)
- Gingival index(baseline)