Evaluation of efficacy of 0.3% Nutmeg (Myristica fragrans) Gel as Local Drug Delivery in smokers with Stage-II Periodontitis – A Randomised clinical study

PREPARATION OF NUTMEG GEL

A 5 g of nutmeg powder will be mixed with 100 ml of distilled water

The obtained solution will be heated at 65 degrees centigrade for 15 minutes resulting in nutmeg extract

Then 2 ml of propylene glycol

4 ml of 95 percentage

ethanol  0.12 g methyl paraben

0.01 ml triethanolamine

0.05 mg piperine  and

150 mg of carbopol

934 will be added to 20 ml of distilled water

and a thick mixture will be obtained

To this mixture 1 ml of nutmeg extract will be added to obtain 30 g of 0.3percentage nutmeg gel

STUDY PROCEDURE

A total of 70 stage-II periodontitis patients who are current smokers will be allocated Randomly Using

Simple Simple Randomisation

Lot Method to Group A 35 patients

and Group B 35 patients

Group   A

Patients will be subjected to SRP alone

Group  B

Along with SRP 1 ml of 0.3 percentage nutmeg gel will be injected into the periodontal pocket with the help of

a syringe immediately after SRP

Patients will be given instructions to avoid hard or sticky foods, and brushing or using interdental aids will

be refrained from near the treated areas for one week. Patients will be scheduled for a review after three

months

After 3 months PPD and CAL will be recorded and sent for statistical analysis

Inclusion Criteria

Smokers aged between 25-55years  ASA-II

Have a probing pocket depth  of 5 mm or more

Having clinical attachment loss between 3 to 4 mm

No history of periodontal therapy in the preceding 6 months

No use of antibiotics in the preceding 6 months

Exclusion Criteria

Subjects with allergies

Tobacco users in any form other than smoking

Immunocompromised individuals

PARAMETERS TO BE ANALYSED

Probing pocket depth and Clinical Attachment Level before application of 0.3 percentage nutmeg gel

and 3 months after application of 0.3 percentage nutmeg gel