Triggering of Follicular Maturation Using Human Chorionic Gonadotrophin With Gonadotrophin Releasing Hormone Agonist Versus Human Chorionic Gonadotrophin Alone in Antagonist Protocol in Assisted Reproductive Technology : a Randomized Controlled Trial
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- Number of M II oocytes in both groups
研究概览
简要总结
The follicular phase of the menstrual cycle involves the hourly release of gonadotropin-releasing hormone, which binds to receptors on the gonadotropes. This results in the secretion of follicle stimulating hormone and luteinizing hormone in hourly pulses that regulate follicular growth. At midcycle, rapidly rising estradiol from the dominant follicle and a small rise in progesterone lead to a gonadotrophic surge. An increase in the amplitude of Luteinizing hormone and Follicle stimulating hormone pulses initiates oocyte maturity and triggers ovulation approximately
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Infertile couples wishing to do intracytoplasmic injection trial .
- •first intracytoplasmic injection trial
- •Body mass index:18-
- •5-Antral follicular count: more than 5 follicles in one ovary 6-normal, mild or moderate male factor infertility. 7- Antimullerian hormone >1 ng/ml
排除标准
- •Azoospermic male.
- •Body mass index more than
- •Patients with endometriosis .
- •Antimullerian hormone < 1 ng/ml
研究组 & 干预措施
Human chorionic gonadotrophin group
Patients will receive Human chorionic gonadotrohpin injection 5000 unit
干预措施: Recombinant Human Chorionic Gonadotrophin (Drug)
Human chorionic gonadotrophin + agonist group
patients will receive both Human chorionic gonadotrophin (2500 unit) and gonadotrophin releasing hormone agonist 1mg leuprolide acetate
干预措施: human chorionic gonadotrophin + gonadotrophin releasing hormone agonist (Drug)
结局指标
主要结局
Number of M II oocytes in both groups
时间窗: 24 hours
次要结局
- Fertilization rate in each group(3 days)
- Clinical pregnancy rate in each group(15 days)