UZ Brussel Heart Rhythm Management Center Monocentric Registry of Brugada Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 2,000
- 试验地点
- 1
- 主要终点
- Ventricular arrhythmias
研究概览
简要总结
The monocentric UZB registry for Brugada registry is intended to collect all data on patients affected by Brugada syndrome at UZ Brussel hospital (UZB).
详细描述
The monocentric UZB registry for Brugada registry is intended to collect all data on patients affected by Brugada syndrome.
These includes:
- demographical data: age, sex
- antropometric data: height, weight, BMI
- clinical data: comorbidities, arrhythmias, PM or ICD implantation, therapy
- data on the families: number of family members, sudden death history. 4) data on the genetics 5) data on: ECG, echocardiography, CT scan, MRI of heart, MRI of brain, ECG imaging, 3D electroanatomical mapping and ablation
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Brugada syndrome diagnosis
排除标准
- •Other diagnosis different from Brugada syndrome
结局指标
主要结局
Ventricular arrhythmias
时间窗: through study completion, an average of 10 year
Composite of: sudden cardiac death, aborted sudden cardiac death, ventricular fibrillation, sustained ventricular tachycardia, ICD appropriate therapy
Atrial fibrillation
时间窗: through study completion, an average of 10 year
Atrial fibrillation occurrence
Cardiovascular death
时间窗: through study completion, an average of 10 year
Death for cardiovascular cause
Death for any cause
时间窗: through study completion, an average of 10 year
Death for any cause
Genetic mutations
时间窗: Baseline
Genetic mutations (pathogenic and variant of unknown significance) associated with Brugada syndrome. Wide gene panel with next generation sequencing will be used: Roche SeqCap® EZ Human Exome Probes v3.0 for BrS.
次要结局
未报告次要终点
研究者
Carlo de Asmundis
Director of Heart Rhythm Management Center
Universitair Ziekenhuis Brussel