UZ Brussel HRMC Registry of Brugada Syndrome

Recruiting

• Conditions: Brugada Syndrome

• Registration Number: NCT05283759
• Lead Sponsor: Universitair Ziekenhuis Brussel

Brief Summary

The monocentric UZB registry for Brugada registry is intended to collect all data on patients affected by Brugada syndrome at UZ Brussel hospital (UZB).

Detailed Description

The monocentric UZB registry for Brugada registry is intended to collect all data on patients affected by Brugada syndrome.

These includes:

1. demographical data: age, sex

2. antropometric data: height, weight, BMI

3. clinical data: comorbidities, arrhythmias, PM or ICD implantation, therapy

3) data on the families: number of family members, sudden death history. 4) data on the genetics 5) data on: ECG, echocardiography, CT scan, MRI of heart, MRI of brain, ECG imaging, 3D electroanatomical mapping and ablation

Study Timeline

• Study Start: 1992-01-01
• Study First Submitted: 2022-02-23
• Status Verified: 2022-03
• Study First Submitted QC: 2022-03-12
• Last Update Submitted: 2022-03-12
• Study First Posted: 2022-03-17
• Last Update Posted: 2022-03-17
• Primary Completion: 2032-01-01
• Study Completion: 2032-01-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 2000

Inclusion Criteria

• Brugada syndrome diagnosis

Exclusion Criteria

• Other diagnosis different from Brugada syndrome

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ventricular arrhythmias	through study completion, an average of 10 year	Composite of: sudden cardiac death, aborted sudden cardiac death, ventricular fibrillation, sustained ventricular tachycardia, ICD appropriate therapy
Atrial fibrillation	through study completion, an average of 10 year	Atrial fibrillation occurrence
Cardiovascular death	through study completion, an average of 10 year	Death for cardiovascular cause
Death for any cause	through study completion, an average of 10 year	Death for any cause
Genetic mutations	Baseline	Genetic mutations (pathogenic and variant of unknown significance) associated with Brugada syndrome. Wide gene panel with next generation sequencing will be used: Roche SeqCap® EZ Human Exome Probes v3.0 for BrS.

Trial Locations

Locations (1)

UZ Brussel Heart Rhythm Management Center; 🇧🇪 Brussels, Belgium