Investigation for clinical factors contributing to accelerated long-term forgetting in epilepsy patients

Not Applicable

• Conditions: ocalization Related Epilepsy

• Registration Number: JPRN-UMIN000029570
• Lead Sponsor: Department of Neurology, Neurological Institute, Graduate School of Medicine, Kyushu University

Brief Summary

Multiple regression analyses showed a significant association between the left CA1 volume and the 1-week story retention, but this was not found for the whole hippocampus or other subfield volumes. Hippocampal shape analyses revealed that atrophy of the superior-lateral, superior-central, and inferior-medial regions of the left hippocampus, corresponding to CA1 and CA2/3, was associated with the verbal retention rate.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-10-26
• Study Completion: 2020-03-31
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Not provided

Exclusion Criteria

1. Estimated full scale IQ <70 2. Suspected aphasia with a screening test 3. History of epilepsy surgery 4. Neurological and psychiatric comorbidities 5. Any contraindications to MRI 6. History of residency in specific cities(Yanagawa city, Yukuhashi city and Beppu city) where movies for original neuropsychological examination were filmed

Study & Design

• Study Type: Interventional
• Study Design: Not specified