Taurolidine Lock in Long Term Parenteral Nutrition

Phase 4

Completed

• Conditions: Home Parenteral Nutrition; Central Venous Catheter
• Interventions: Drug: 2% Taurolidine Lock; Drug: 1.35% Taurolidine

• Registration Number: NCT02009189
• Lead Sponsor: Stanley Dudrick's Memorial Hospital

Brief Summary

Taurolidine alone or in combination with citrate have been proposed for locking the catheter to reduce the number of catheter infections. As there is not enough evidence to give recommendations in this regard, the study tested the hipothesis that taurolidine improves the outcome of long term paretneral nutrition.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-11
• Primary Completion: 2013-11
• Status Verified: 2013-12
• Study Completion: 2013-12
• Study First Submitted: 2013-12-08
• Study First Submitted QC: 2013-12-10
• Last Update Submitted: 2013-12-10
• Study First Posted: 2013-12-11
• Last Update Posted: 2013-12-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• home parenteral nutrition for at least months before enrollment
• presence of central venous cathter

Exclusion Criteria

• home nutrition < 12 months
• catheter in peripheral vein

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Control	2% Taurolidine Lock	Saline flush
1.35% Taurolidine with citrate	1.35% Taurolidine	Catheter lock with 1.35% Taurolidine + citrate
Control	1.35% Taurolidine	Saline flush
2% Taurolidine lock	2% Taurolidine Lock	Catheter lock with 2% Taurolidine
2% Taurolidine lock	1.35% Taurolidine	Catheter lock with 2% Taurolidine
1.35% Taurolidine with citrate	2% Taurolidine Lock	Catheter lock with 1.35% Taurolidine + citrate

Primary Outcome Measures

Name	Time	Method
Number of CVC infections	12 months	Number of central venous catheter infections

Trial Locations

Locations (1)

Stanley Dudrick's Memorial Hospital; 🇵🇱 Skawina, Poland