Normative Values for the German Version of the Montreal Cognitive Assessment (MoCA)

Completed

• Conditions: Dementia Alzheimers; Cognitive Impairment; Cognition Disorders; Cognitive Abnormality; Cognition Disorders in Old Age; Dementia, Alzheimer Type; Cognitive Change; Cognitive Deterioration; Cognitive Impairment, Mild; Dementia, Mild
• Interventions: Diagnostic Test: MoCA

• Registration Number: NCT03246269
• Lead Sponsor: Andreas Monsch

Brief Summary

This observational cohort study in healthy volunteers establishes normative data for the German version of the Montreal Cognitive Assessment (MoCA) and investigates the possible impacts of demographics on the MoCA total score.

Detailed Description

The Montreal Cognitive Assessment (MoCA) is a short tool to evaluate a multitude of cognitive domains (visuospatial / executive functioning, object naming, memory, attention, language, abstraction, orientation). The original English MoCA consistently showed very high sensitivity and specificity in distinguishing patients with mild cognitive impairment from healthy controls. Therefore it is an excellent tool for early recognition of cognitive disorders. Based on a Canadian sample, the MoCA proposes a cut-off-value of 26/30 points. However, there is increasing evidence of intercultural differences in terms of the best cut-off-score. In addition the original version only slightly corrects for possible influences of education - an adjustment for age- or gender-related effects is missing. Therefore, the aim of our study was to investigate the possible impacts of demographics on the MoCA total score and to provide normative values for a German-speaking population.

Study Timeline

• Study Start: 2016-12
• Primary Completion: 2017-04
• Study Completion: 2017-04
• Study First Submitted: 2017-08-08
• Study First Submitted QC: 2017-08-08
• Study First Posted: 2017-08-11
• Status Verified: 2018-05
• Last Update Submitted: 2018-05-30
• Last Update Posted: 2018-05-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 334

Inclusion Criteria

• Age ≥65 years
• Education ≥7 years
• Fluency in the German language
• Written informed consent

Exclusion Criteria

• History of cognitive impairment
• Depression
• Severe sensory or motor impairment interfering with cognitive testing
• Serious somatic disease
• Disease or event affecting the central nervous system
• Cerebrovascular disease
• Regular medication with psychoactive drugs except for benzodiazepines
• Participation in a cognitive study within the last 3 months

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
MoCA cohort	MoCA	The German MoCA is administered once to all study participants.

Primary Outcome Measures

Name	Time	Method
Montreal Cognitive Assessment (MoCA) - German version	Baseline	Total score of the MoCA

Secondary Outcome Measures

Name	Time	Method
Mini-Mental State Examination (MMSE)	Baseline	Total score of the MMSE
Geriatric Depression Scale (GDS)	Baseline	Total score of the GDS
Consortium to Establish a Registry for Alzheimer's Disease - Neuropsychological Assessment Battery (CERAD-NAB)	Baseline	Total score of the CERAD-NAB