The effect of probiotics on fertility
Phase 2
- Conditions
- Recurrent implantation failure.Complication associated with artificial fertilization, unspecifiedN98.9
- Registration Number
- IRCT20160422027520N20
- Lead Sponsor
- Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Female
- Target Recruitment
- 50
Inclusion Criteria
Patients from East Azerbaijan
Having at least three implantation failures
Do not have any type of immunotherapy in their medical history.
Having regular menstrual cycles
Exclusion Criteria
Patients under 18 years old and over 41 years old
Patients with coagulation problems.
Patients with intrauterine anomalies.
Having chromosomal abnormalities
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The frequency of Th1 and Th2 cells. Timepoint: Before and after interference. Method of measurement: By using flow cytometry.;Investigating the expression level of transcription factors T-bet and GATA3. Timepoint: Before and after interference. Method of measurement: By using Quantitative Real time PCR.;Examining the expression level of cytokines IL-4, IL-10, IFN?, TNFa. Timepoint: Before and after interference. Method of measurement: By using Quantitative Real time PCR.;Investigating the secretion of cytokines IL-4, IL-10, IFN?, TNFa. Timepoint: Before and after interference. Method of measurement: using sandwich ELISA method.
- Secondary Outcome Measures
Name Time Method Pregnancy rate. Timepoint: After positive beta-hCG test, clinical pregnancy was evaluated at 5-6 week. Method of measurement: Examining the formation of gestational sac using Sonography method.