The effects of prazosin on Rapid Eye Movement (REM) sleep and emotional memory in healthy young adults
- Conditions
- Post Traumatic Stress Disorder (PTSD)Mental Health - Studies of normal psychology, cognitive function and behaviour
- Registration Number
- ACTRN12615000535572
- Lead Sponsor
- School of Psychological Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 20
Aged 18-39, healthy, with a consistent sleep schedule
- Regular sleep/wake schedule not corresponding to the night/day cycle (e.g. shift workers), any sleep disorders.
- Personal history of Axis 1 psycho-pathology, or family history of mood and psychotic disorders.
- History of head injuries, loss of consciousness above 15 minutes, migraines requiring treatment, or seizures.
- Current use of psychotropic medications or a positive urinary toxicology for illegal substances.
- Current use of medication that affects the central-nervous system (e.g. Beta-blockers or anti-depressants)
- Consumption of > 14 standard drinks of alcohol per week
- Smokers or people undergoing nicotine replacement therapies (unless ceased over 12 months ago)
- Consumption of > 300mg of caffeine per day
- Use of erectile dysfunction medication
- Use of other hypertension drugs
- Severe peripheral edema
- Supine hypotension and/or clinically meaningful hypotension
- Plans to have any medical or dental procedures requiring general anesthetic during the study
- Are pregnant or trying to get pregnant during the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method