Prognostic Value of Transthoracic Diaphragmatic Echography in COVID-19 Pneumonia Patients With Acute Respiratory Failure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 171
- 试验地点
- 1
- 主要终点
- Early diaphragm ultrasound as a predictor factor for invasive and non invasive ventilation and death
研究概览
简要总结
We hypothesized that diaphragm thickness is concerned in acute respiratory failure of COVID19 patients and its ultrasound measure at the begining of hospitalisation is a good predictor of poor outcome.
A prospective observational non intervention study is designed.
详细描述
To answer our hypothesis we will perform diaphragm ultrasound in the first 24hr hospitalized COVID19 patients.
In the ultrasound exploration we will assess diaphragm movility and thickness. We will also assess other clinical, biochemistry and radiological variables. The main outcome we want to analyze is the destination on discharge: home, respiratory intermediate critical unit or exitus.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •COVID19 Pneumonia Acute respiratory failure (PaO2 <60mmHg)
排除标准
- •Invasive or non invasive ventilation within first 24h Neuromuscular disease Diaphragmatic paralysis
结局指标
主要结局
Early diaphragm ultrasound as a predictor factor for invasive and non invasive ventilation and death
时间窗: From date of inclusion until discharge date (lenght of hospitalization)
This is the main outcome of our study given that it has a important clinical implications. If we confirm our hypothesis diaphragm ultrasound could prove to be a useful prognosis tool for COVID19 patients.
次要结局
- Diaphragm thickness rate as a predictor factor for invasive and non invasive ventilation and death(From date of inclusion until discharge date (lenght of hospitalization))
- Diaphragm movility rate as a predictor factor for invasive and non invasive ventilation and death(From date of inclusion until discharge date (lenght of hospitalization))
研究者
Javier Lázaro
MD; PhD
Aragon Institute of Health Sciences