NCT01623817已完成不适用
Effectiveness of Vancomycin Loading Therapy
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Time duration for concentration of vancomycin to reach target trough of 15-20 mg/L
研究概览
简要总结
The goal of tish clinical research study is to identify that loading of vancomycin can facilitate rapid attainment of target trough serum vancomycin concentration.
详细描述
The Study drug
- Vancomycin : a glycopeptide antibiotic, is the first line agent in the treatment of methicillin resistant staphylococcus aureus
Study design : Randomized controlled trials
Study Drug Administration
- If your doctor believes you are eligible, and you agree to take part in this study, you will be randomized to two treatment groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Admission to Samsung Medical Center MICU and general wards for infectious diseases and hematology division
- •Patients with SIRS (systemic inflammatory response syndrome)
- •Intravenous vancomycin therapy deemed necessary
排除标准
- •Age less than 20 years
- •Age more than 75 years
- •Current renal insufficiency defined as estimated Glomerular filtration rate < 50mg/min/1.73 m2 by MDRD equation
- •History of adverse events to vancomycin
- •Pregnant woman
研究组 & 干预措施
Vancomycin loading
Experimental
This group is received loading dose 30mg/kg. Subsequent doses of vancomycin are considered standard of care.
干预措施: Vancomycin HCL (Drug)
结局指标
主要结局
Time duration for concentration of vancomycin to reach target trough of 15-20 mg/L
时间窗: Peak level drawn 1 hour after the completion of loading dose. Sequential trough level drawn 30 min before each standard dose for the next 4 doses.
次要结局
- Adverse event rate in each arm, including nephrotoxicity and rash.(7 days post-treatment)
研究者
研究点 (1)
Loading locations...
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