Effect of Oral Zinc Sulfate Supplementation on Enzymes of Urate Pathway in Spermatozoa and Seminal Plasma of Iraqi Asthenospermic Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 2
- 主要终点
- Measurement the uric acid level in spermatozoa and seminal plasma by using spectrophotometer.
研究概览
简要总结
Although many reports have investigated the relationship between subfertility and uric acid levels in semen, to the best of author knowledge, there is no study have been published to yet focus on the effects of asthenospermia treatments, such as given an oral zinc supplementation, on the activity of urate-related enzymes, which are important in fertility of human.
详细描述
The present study was designed to investigate the effect of zinc supplementation on the qualitative and quantitative characteristics of semen, along with uric acid levels and urate-related enzymes in the seminal plasma and spermatozoa of asthenospermic males.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 26 Years 至 36 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •The presence of asthenozoospermia in the semen sample.
- •Must be unable to reproduce.
排除标准
- •the absence of endocrinopathy, varicocele, and female factor infertility. Smokers and alcoholic men were excluded from the study because of their recognized high seminal ROS levels and decreased antioxidant levels.
研究组 & 干预措施
Healthy control
60 fertile (age 31.6±3.3 year) men, no treatment.
Zinc sulfate
60 subfertile (age 32.5±3.23 year) men with asthenozoospermia was treated with zinc sulfate, every participant took two capsules of zinc sulfate per day for three months (each one 220 mg).
干预措施: Zinc Sulfate (Dietary Supplement)
结局指标
主要结局
Measurement the uric acid level in spermatozoa and seminal plasma by using spectrophotometer.
时间窗: up to three months.
Clinical parameter
次要结局
- Measurement the adenosine deaminase activity in spermatozoa and seminal plasma by using spectrophotometer.(up to three months.)
- Measurement the 5'-nucleotidase activity in spermatozoa and seminal plasmaby using the spectrophotometer.(up to three months.)
- Measurement the xanthine oxidase activity in spermatozoa and seminal plasma by using spectrophotometer.(up to three months.)
研究者
mahmoud hussein hadwan
Principal Investigator Dr. Mahmoud Hussein Hadwan
Babylon University