Weight Loss and Cognitive Function in Middle-Aged and Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- Cognitive function changes - attention
研究概览
简要总结
More than two-thirds of middle-aged and older adults are overweight, which places them at greater risk of disability and higher medical expenses. Lifestyle interventions which promote weight loss for this population are needed. However, it is not known how different weight loss approaches impact brain (cognitive) functions, such as memory and attention. The investigator's investigation aims to improve adherence to a hypocaloric diet prescription through improved attention and inhibitory control, reduced hunger, and increased satiety.
The objectives of this pilot study are to: 1) determine the feasibility and establish proof-of-concept; 2) establish proficiency and feasibility of the proposed cognitive function assessments; and 3) obtain preliminary data for effect size generation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 50 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Overweight or obese, BMI 25-40 kg/m^2
- •Able to use a computer, keyboard, and mouse
排除标准
- •Uncontrolled hypertension
- •Orthopedic injury
- •Other conditions that preclude participation in a walking program
- •Previous participation in psychology research which involved computerized cognitive testing
- •Diabetes which requires insulin
研究组 & 干预措施
Hypocaloric diet with hunger reduction strategy
Participants will be prescribed a hypocaloric diet with additional instructions to promote hunger reduction. The hypocaloric diet will range 1200-1500 kcal/d, and will be based upon the 2015 US Dietary Guidelines for Americans. Dietary instructions will be provided by a Registered Dietitian.
干预措施: Hypocaloric diet with hunger reduction strategy (Behavioral)
Hypocaloric diet without hunger reduction strategy
Participants will only be prescribed a hypocaloric diet. The hypocaloric diet will range 1200-1500 kcal/d, and will be based upon the 2015 US Dietary Guidelines for Americans. Dietary instructions will be provided by a Registered Dietitian.
干预措施: Hypocaloric diet without hunger reduction strategy (Behavioral)
结局指标
主要结局
Cognitive function changes - attention
时间窗: 30-min measurement per session
Computerized tasks will score each participant's performance for attention at baseline and after both the 4-week weight loss and weight maintenance phases.
Cognitive function changes - inhibitory control
时间窗: 30-min measurement per session
Computerized tasks will score each participant's performance for inhibitory control at baseline and after both the 4-week weight loss and weight maintenance phases.
Weight change
时间窗: 5-min measurement per session
Weight will be measured on a scale at baseline and after both the 4-week weight loss and weight maintenance phases.
次要结局
- Perceived hunger(15-minute measurement per session)
研究者
Brenda Davy
Professor
Virginia Polytechnic Institute and State University