Environmental Chemicals and Their Role in Obesity

• Conditions: Obesity

• Registration Number: NCT01778868
• Lead Sponsor: University Hospital, Antwerp

Brief Summary

Hormonal disruption is the inappropriate alteration of the hormonal system by chemical substances that are present in our environment. Some chemical substances are capable of replicating, enhancing or reducing the production, release, transport or action of natural hormones. Therefore, they are called hormonal or endocrine disrupters. Some 'classic' endocrine disrupters such as pesticides and dioxins are considered responsible for infertility, cancer and thyroid problems. Recently, a number of additional chemical substances were stipulated to have endocrine disrupting capabilities. The industrial production of these substances in large quantities has led to an accumulation in our environment and thus possible negative consequences on human health.

The aim of this study is to investigate the rol of these chemical substances in the occurence of overweight and obesity.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-08
• Status Verified: 2013-01
• Study First Submitted: 2013-01-18
• Study First Submitted QC: 2013-01-28
• Last Update Submitted: 2013-01-28
• Study First Posted: 2013-01-29
• Last Update Posted: 2013-01-29
• Primary Completion: 2013-03
• Study Completion: 2013-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 203

Inclusion Criteria

• adult
• Overweight (BMI > 25 kg/m²) or obesity (BMI > 30 kg/²)

Exclusion Criteria

• Type 1 diabetes mellitus
• psychiatric illness

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum levels of polychlorinated biphenyls	at the moment of entering a weight loss program	The following PCB congeners are measured (official IUPAC number is given): CB 28 CB 52 CB 74 CB 95 CB 99 CB 101 CB 105 CB 118 CB 149 CB 146 CB 153 CB 138 CB 187 CB 183 CB 128 CB 167 CB 174 CB 177 CB 171 CB 172 CB 156 CB 180 CB 170 CB 199 CB 196/203 CB 194 CB 206 CB 209
serum levels of polybrominated diphenyl ethers	at the moment of entering a weight loss program	The following polybrominated diphenyl ethers (BDE) are measured: BDE 28 BDE 47 BDE 100 BDE 99 BDE 154 BDE 153 BDE 183
change in urine levels of pollutants compared to the level at the start of the weight loss program	after 3,6 and 12 months of weight loss	The pollutants detected in urine comprise of bisphenol A, triclosan, phtalates
serum levels of organochlorine pesticides	at the moment of entering a weight loss program	The following organochlorine pesticides are measured: alfa- hexachlorocyclohexane, beta-hexachlorocyclohexane, gamma-hexachlorocyclohexane Hexachlorobenzen Ocychlordane Transnonachlor p-p-dichlorodiphenyltrichloroethane, p,p'-dichlorodiphenyldichloroethylene pp-dichlorodiphenyldichloroethane
Change in serum levels of polychlorinated biphenyls compared to the levels at the start of the weight loss program	after 3, 6 and 12 months of weight loss	The following PCB congeners are measured (official IUPAC number is given): CB 28 CB 52 CB 74 CB 95 CB 99 CB 101 CB 105 CB 118 CB 149 CB 146 CB 153 CB 138 CB 187 CB 183 CB 128 CB 167 CB 174 CB 177 CB 171 CB 172 CB 156 CB 180 CB 170 CB 199 CB 196/203 CB 194 CB 206 CB 209
Change in serum levels of organochlorine pesticides compared to the level at the start of the weight loss program	after 3,6 and 12 months of weight loss	The following organochlorine pesticides are measured: alfa- hexachlorocyclohexane, beta-hexachlorocyclohexane, gamma-hexachlorocyclohexane Hexachlorobenzen Ocychlordane Transnonachlor p-p-dichlorodiphenyltrichloroethane, p,p'-dichlorodiphenyldichloroethylene pp-dichlorodiphenyldichloroethane
Serum levels of hydroxylated metabolites of polychlorinated biphenyls	at the moment of entering a weight loss program	The following hydroxylated metabolites of polychlorinated biphenyls are measured 4-HO-CB79 4-HO-CB120 3HO-CB118 4HO-CB107 3HO-CB153 4HO-CB146 4HO-CB127 3HO-CB138 4HO-CB130 4HO-CB163 4HO-CB187 4-HO-CB162 4-HO-CB177 3HO-CB180 4HO-CB172 4HO-CB193 4-diMeO-CB202 4-HO-CB208
Change in serum levels of polybrominated diphenyl ethers compared to the level at the start of the weight loss program	After 3,6 and 12 months of weight loss	The following polybrominated diphenyl ethers (BDE) are measured: BDE 28 BDE 47 BDE 100 BDE 99 BDE 154 BDE 153 BDE 183
Urinary levels of pollutants	at the moment of entering a weight loss program	The pollutants detected in urine comprise of bisphenol A, triclosan, phtalates
change in serum levels of hydroxylated metabolites of polychlorinated biphenyls compared to the level at the start of the weight loss program	after 3,6 and 12 months of weigth loss	The following hydroxylated metabolites of polychlorinated biphenyls are measured 4-HO-CB79 4-HO-CB120 3HO-CB118 4HO-CB107 3HO-CB153 4HO-CB146 4HO-CB127 3HO-CB138 4HO-CB130 4HO-CB163 4HO-CB187 4-HO-CB162 4-HO-CB177 3HO-CB180 4HO-CB172 4HO-CB193 4-diMeO-CB202 4-HO-CB208

Trial Locations

Locations (1)

University Hospital Antwerp; 🇧🇪 Edegem, Antwerpen, Belgium