NCT00920270Unknown3 期
Efficacy and Safety of Nebulized Colistin for Adjunctive Therapy of Hospital-Acquired Pneumonia Caused by Gram Negative Bacteria
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 入组人数
- 140
- 试验地点
- 1
- 主要终点
- Clinical response
研究概览
简要总结
Nebulized Colistin for Adjunctive Therapy of Hospital-Acquired Pneumonia caused by Gram Negative Bacteria should be more effective than conventional therapy
详细描述
Randomized Controlled Clinical Trial in hospitalized adult patients with hospital-acquired pneumonia. The patients are allocated to conventional group or nebulized colistin group. The conventional group receives conventional antibiotics whereas the nebulized colistin group receives nebulized colistin in addition to conventional antibiotics. The outcomes are clinical response and microbiological responses.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult (age>18 years) hospitalized patient with hospital-acquired pneumonia due to Gram negative bacteria
排除标准
- •pregnancy
- •lactating woman
- •colistin allergy
- •severe renal impairment
研究组 & 干预措施
antibiotic
Active Comparator
conventional antibiotics
干预措施: antibiotics (Drug)
colistin group
Experimental
nebulized colistin
干预措施: nebulized colistin (Drug)
结局指标
主要结局
Clinical response
时间窗: 14 days after Treatment
次要结局
- Microbiological response and safety(14 days after treatment)
研究者
研究点 (1)
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Unknown
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