Association of Dietary Magnesium Intake and Circulating Magnesium Concentration With Metabolic Syndrome: A Dose-response Meta-analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Metabolic syndrome risk ratios (Odds ratio, Relative risk, Hazard ratio)
研究概览
简要总结
Magnesium is an essential mineral found in many foods; rich sources include whole grains, green leafy vegetables, coffee, and legumes. Magnesium is a critical cofactor in >300 enzymatic reactions, including those related to energy metabolism. Reduced magnesium intake and serum concentrations have been detected, both cross-sectionally and prospectively,in type 2 diabetes and insulin resistance, hypertension, dyslipidemia, and cardiovascular diseases.
Different studies have reported inadequate magnesium intake and low serum magnesium concentrations may correlated also with metabolic syndrome, defined as a cluster of metabolic disorders including obesity, hypertension, dyslipidemia and impaired glucose tolerance or diabetes mellitus. Previous studies on this subject, however, reported contradicting results. Some investigations reported inadequate magnesium intake and low serum magnesium concentrations while others did not.
To our knowledge, the epidemiological evidence on the relation between dietary magnesium intake and risk of metabolic syndrome has not yet been summarized.Therefore, the investigators will perform a systematic review and dose-response meta-analysis to assess the association between dietary and circulating magnesium level and risk of metabolic syndrome.
详细描述
Background: Increasing evidence has suggested inadequate magnesium intake and low serum magnesium concentrations may correlated with metabolic syndrome. However, whether or not dietary or circulating magnesium at usual intakes or concentrations influences risk of metabolic syndrome is inconsistent
Objective:To our knowledge, the epidemiological evidence on the relation between dietary magnesium intake and risk of metabolic syndrome has not yet been summarized.Therefore, to improve evidence-based guidance for dietary guidelines, the investigators will perform a systematic review and dose-response meta-analysis to assess the association between dietary and circulating magnesium level and risk of metabolic syndrome.
Design: The planning, conduct and reporting of the proposed meta-analyses will follow Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines.
Data search and screening: The PubMed, Cochrane CENTRAL, and EMBASE databases via Elsevier will be searched using appropriate search terms.
Study selection: Published articles will be included: Randomized, controlled studies, case-control studies, cross-sectional studies and cohort studies. All studies enrolled adults (age 18 years) and reported metabolic syndrome as the outcome of interest and magnesium intake or serum magnesium concentration as a risk factor or intervention. They reported adjusted risk ratios, including odds ratios, relative risks, hazard ratios with 95% confidence intervals (CIs), or they reported sufficient data to calculate these values for 3 or more quantitative categories of dietary magnesium intake levels. They reported risk ratios with metabolic syndrome criteria according to the National Cholesterol Education Panel (NCEP), modified NCEP, American Heart Association/National Heart Lung and Blood Institute , and harmonized definition . The investigators selected articles written in English that were published in their entirety.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Dietary studies in humans 18 years old and older
- •Randomized controlled study, Cohort study, Nested case-control study, Case-control study, Cross-sectional study
- •The exposure of interest is magnesium intake (mg/day) or serum magnesium concentration(mmol/L, mg/dL)
排除标准
- •Non-human studies
- •Authors did not make serum magnesium concentration measurement;
- •The outcome values can not be used for meta-analysis
- •Duplicated articles.
- •Studies are not published as full reports, such as conference abstracts and letters to editors
结局指标
主要结局
Metabolic syndrome risk ratios (Odds ratio, Relative risk, Hazard ratio)
时间窗: Baseline
次要结局
- Serum magnesium concentration (mg/dL, mmol/L)(Baseline)
研究者
Ju Sang-yhun
M.D., Ph.D., Clinical Associate Professor
The Catholic University of Korea