A Comparative Study Between the Efficacy of Diode Laser and Nano-chitosan Gel on Activation of Non-vital in- Office Bleaching Agent

Phase 1

• Conditions: Tooth Discoloration
• Interventions: Drug: nano chitosan

• Registration Number: NCT06782087
• Lead Sponsor: Misr University for Science and Technology

Brief Summary

The growing demand for white smile between patients has increased over recent years, the development of techniques and improvement of materials permits searching for beautiful natural smile.

The discoloration of teeth might be intrinsic, extrinsic, or combined. A variety of commercial bleaching agents is available. The most common substances used are carbamide peroxide or hydrogen peroxide or a mixture of sodium perborate and hydrogen peroxide.

Detailed Description

The aim of the study is to assess the effectiveness of two different in-office bleaching materials carbamide peroxide alone and carbamide peroxide with Chitosan nanoparticles Using diode laser as an activator Regarding tooth whitening and color stability 1 Day , 1 weeks, 1 month after treatment using Vita easy shade.

Study Timeline

• Study First Submitted: 2024-12-23
• Study First Submitted QC: 2025-01-13
• Study First Posted: 2025-01-17
• Status Verified: 2025-05
• Study Start: 2025-05-15
• Last Update Submitted: 2025-05-15
• Last Update Posted: 2025-05-21
• Primary Completion: 2025-05-30
• Study Completion: 2025-05-30

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

• discolored crown, non-vital or endodontically treated upper central and lateral incisors
• previous endodontic treatment performed two or more years earlier.

Exclusion Criteria

• caries on upper central and lateral incisors, inadequate fillings, and progressive periodontal disease.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SEQUENTIAL

Arm && Interventions

Group	Intervention	Description
peroxides and sodium perborate and 980nm diode laser.	nano chitosan	peroxides and sodium perborate + 980nm diode laser.

Primary Outcome Measures

Name	Time	Method
Color change	these assessments were performed for 1 day, 1 week, and 1 month after treatment with Vita easy shade.	these assessments were performed for 1 day, 1 week, and 1 month after treatment with Vita easy shade obtaining difference ∆E\* values using colorcoordinates CIE L\*, a\* and b\*
color change using digital vita easy shade guide	1 day , 1 week , 1 month	color change using digital vita easy shade guide

Trial Locations

Locations (1)

Misr University for science and technology; 🇪🇬 Giza, Egypt