An Observed Research: to Assess Kawasaki Disease with Cardiovascular Imaging
Overview
- Phase
- Not Applicable
- Status
- Enrolling By Invitation
- Sponsor
- West China Second University Hospital
- Enrollment
- 500
- Locations
- 1
- Primary Endpoint
- Major adverse cardiovascular events
Overview
Brief Summary
The goal of this observational study is to assess the cardiovascular injury of Kawasaki disease with multi-modal imaging combined with clinical data.
During their disease progress, participants will undergo cardiovascular magnetic resonance, echocardiography, electrocardiography, laboratory tests, and genetic tests when hospitalization and follow-up, and the baseline data will be collected at the admission. Some patients will undergo coronary computed tomography angiography (CCTA) or DSA due to the disease progress. All the above examination data and changes will be analyzed to assess the value of cardiovascular imaging in the pathogenesis, diagnosis, and prognosis of Kawasaki disease.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- — to 18 Years (Child, Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Patients diagnosed based on the American Heart Association guideline for Kawasaki disease.
Exclusion Criteria
- •Patients with a history of congenital heart disease, cardiomyopathy.
- •Patients with age over 18 years old.
Outcomes
Primary Outcomes
Major adverse cardiovascular events
Time Frame: 10 years after the onset
Major adverse cardiovascular events including cardiac death, transient ischemic attack or stroke, myocardial infarction, arrhythmia, heart failure, severe valvular disease, percutaneous coronary intervention, coronary artery bypass graft, and other cardiovascular surgery.
Secondary Outcomes
No secondary outcomes reported
Investigators
Ling-Yi Wen
Principal Investigator
West China Second University Hospital