Does salt and glycerol improve tolerance to fainting compared to salt alone?

Not Applicable

Completed

• Conditions: Vasovagal syncope; Circulatory System

• Registration Number: ISRCTN87675635
• Lead Sponsor: Ministry of Defence

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2023-01-05
• Study Start: 2023-10-04
• Last Update Posted: 16 October 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

1. Healthy with no active medical treatment or taking regular medications or supplements (excluding contraceptives)
2. Aged 18-55 years

Participants who entered into the RCT aspect of the study:
3. Prior orthostatic mediated syncope or prior non-orthostatic mediated reflex syncope

Exclusion Criteria

1. Individuals who are competing in competitive sports, for which glycerol supplementation is forbidden by WADA, will be excluded.
2. Volunteers taking ergogenic supplements within in the last month will be excluded.
3. Any participant with ongoing medical condition(s) which could be worsen with expansion of plasma volume will be excluded including those whom identify as having cardiovascular or neurological disease.
4. Participants taking prescription medications which could interfere with testing will be excluded
5. Participants who are pregnant or whom believe they may be pregnant, will be excluded

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time to presyncope as measured for head-up tilt with lower body negative pressure pre and post intervention

Secondary Outcome Measures

Name	Time	Method
A difference in cardiovascular variables during head up tilt with lower body negative pressure pre and post intervention