An International Multicenter Retrospective Analysis of RATS, VATS and Open Lung Resections After Neoadjuvant Chemo-immunotherapy
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Non-Small Cell Lung Cancer
- Sponsor
- Scientific Institute San Raffaele
- Enrollment
- 140
- Locations
- 6
- Primary Endpoint
- The perioperative complication of video-assisted thoracoscopic surgery (VATS) approach
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
The study is a retrospective observational study. The study is designed to be multicentric and international and it will analyze medical records from selected patients diagnosed with locally advanced and resectable NSCLC who underwent lung resection by robotic, VATS and open approach after receiving neoadjuvant chemo-immunotherapy.
There are no risks for the patients, as this is a retrospective data collection.
Detailed Description
The use of neoadjuvant chemo-immunotherapy for the treatment of non-small cell lung cancer (NSCLC) is increasing. However, there is limited research comparing the feasibility and oncologic efficacy of robot-assisted thoracoscopic surgery (RATS), video-assisted thoracoscopic surgery (VATS), and open lung resection, in patients already treated with neoadjuvant chemo-immunotherapy. This study aims to evaluate the benefits of RATS compared to VATS and open surgery in terms of short-term outcomes for patients with NSCLC undergoing neoadjuvant chemo-immunotherapy. All adult patients diagnosed with locally advanced and resectable NSCLC who underwent lung resection from 01-01-2016 to 31-03-2024 by robotic, VATS and open approach after receiving neoadjuvant chemo-immunotherapy will be included. Patients are divided into three groups: robotic lung resection; video-assisted thoracoscopic (VATS) lung resection; open lung resection.
Investigators
Pierluigi Novellis
Principal Investigator
Scientific Institute San Raffaele
Eligibility Criteria
Inclusion Criteria
- •Diagnosis of clinical or pathological stage IIB (T1-2, hilar N1, M0) and III (any T, N1-2, M0) NSCLC surgically treated with robotic, VATS and open approach with radical intent from 1st of January 2016 to 31st of March 2024
- •Received neoadjuvant chemo-immunotherapy or immunotherapy alone
- •Age \>= 18 years old at the moment of surgery
Exclusion Criteria
- •Age \<18 years old at the moment of surgery
Outcomes
Primary Outcomes
The perioperative complication of video-assisted thoracoscopic surgery (VATS) approach
Time Frame: 30-90 days after surgery
The investigators will measure the perioperative complications of VATS approach in patients who received neoadjuvant chemo-immunotherapy. Complications will be categorized according to the Clavien-Dindo scale.
The perioperative complications of robotic approach
Time Frame: from the surgery at 30-90 days after
The investigators will measure the perioperative complications of robotic lung resection in patients who received neoadjuvant chemo-immunotherapy. Complications will be categorized according to the Clavien-Dindo scale.
The perioperative complications of the open approach
Time Frame: 30-90 days after surgery
The investigators will measure the perioperative complications of open approach in patients who received neoadjuvant chemo-immunotherapy. Complications will be categorized according to the Clavien-Dindo scale.
Secondary Outcomes
- Duration of surgery(from 30 days after surgery)
- Quality of lymphadenectomy(from 30 days after surgery)
- Conversion rate(from 30 days after surgery)
- Radicality of the resection(from 30 days after surgery)
- Oncological treatment(from 30 days after surgery)
- Survival analysis(from 3 to 5 years after surgery)