The transition into habitual smoking in high-risk adolescents

Recruiting

Conditions: nicotine dependence
Addiction
Nicotine Dependence

Registration Number: NL-OMON46318

Lead Sponsor: Radboud Universiteit Nijmegen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 147

Inclusion Criteria

Experimental smokers
1) Smoked 5-500 cigarettes lifetime
2) Smoked in the last 6 months
3) Never smoked on a daily basis;Controls
1) Never smoked a complete cigarette;All participants
1) Age 12-18

Exclusion Criteria

All participants
1) Use of psychoactive medication that cannot be stopped for 24 hours before scanning
2) fMRI contraindications
3) A history of neurological disease

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter for RQ1 is the number of smoked cigarettes per day at<br /><br>baseline, 6, and 12-month follow-up. The main study parameter for RQ2 is brain<br /><br>activation in the ventral and dorsal striatum in response to smoking cues at<br /><br>baseline and at 1-year follow-up. Inclusion of participants will end when the<br /><br>planned number of participants finished the first EMA and baseline<br /><br>measurements. The study will end when the planned number of participants<br /><br>finished all study procedures. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Fagerström test for Nicotine Dependence (FTND) to measure nicotine<br /><br>dependence.<br /><br>- Hooked on nicotine checklist (HONC) to measure the development of symptoms of<br /><br>nicotine dependence.<br /><br>- The Autonomy Over Tobacco Scale (AOTS) to assess autonomy over smoking and<br /><br>cue-induced craving.<br /><br>- Self - Report Habit Index (SRHI) to measure habit behaviour regarding<br /><br>smoking.<br /><br>- Pleasure of smoking questionnaire (PSQ) to measure to which extend<br /><br>participants experience pleasure from smoking.<br /><br>- Task performance on tthe digit span test and the Two-Step task</p><br>