Intermediate Term Effect of Captopril on Left Ventricle Global Longitudinal Strain in Patients With Duchenne Myodystrophy
试验速览
- 阶段
- 早期 1 期
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- The impaired global longitudinal strain will change in echo in the number of participants with duchenne myodystrophy
研究概览
简要总结
To outline the intermediate term effect of prescribing Captopril as an add on therapy on Left ventricular functions as measured by Global longitudinal strain in patients with Duchenne myodystrophy (DMD)
详细描述
ACEI slowing down the onset and the progression of dystrophinopathic cardiomyopathy.
To outline the intermediate term effect of prescribing Captopril as an add on therapy on Left ventricular functions as measured by Global longitudinal strain in patients with Duchenne myodystrophy (DMD
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 6 Years 至 —（Child, Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Genetically confirmed Duchenne myodystrophy (DMD) patients with abnormal GLS < -18% with minimum age of 6 years old.
排除标准
- •Any patient who refuses to sign an informed consent.
- •Contraindication to ACEI: hypersensitivity - renal impairment - bilateral renal artery stenosis - aortic valve stenosis - hyperkalemia - hypotension.
- •Reduced ejection fraction below 50%.
研究组 & 干预措施
Duchenne patients subjected to captopril
干预措施: Captopril Tablets (Drug)
结局指标
主要结局
The impaired global longitudinal strain will change in echo in the number of participants with duchenne myodystrophy
时间窗: 6 months
Impaired Global longitudinal strain will be changed in echo after 6 months of treatment with Captopril in patients with duchenne myodystrophy
次要结局
未报告次要终点