Effect of Captopril on GLS in Duchenne Myodystrophy

Early Phase 1

Recruiting

• Conditions: Effect of Drug
• Interventions: Drug: Captopril Tablets

• Registration Number: NCT06485661
• Lead Sponsor: Ain Shams University

Brief Summary

To outline the intermediate term effect of prescribing Captopril as an add on therapy on Left ventricular functions as measured by Global longitudinal strain in patients with Duchenne myodystrophy (DMD)

Detailed Description

ACEI slowing down the onset and the progression of dystrophinopathic cardiomyopathy.

To outline the intermediate term effect of prescribing Captopril as an add on therapy on Left ventricular functions as measured by Global longitudinal strain in patients with Duchenne myodystrophy (DMD

Study Timeline

• Study Start: 2024-01-01
• Status Verified: 2024-06
• Study First Submitted: 2024-06-27
• Study First Submitted QC: 2024-06-27
• Study First Posted: 2024-07-03
• Last Update Submitted: 2024-07-13
• Last Update Posted: 2024-07-16
• Primary Completion: 2024-09-30
• Study Completion: 2024-09-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

• Genetically confirmed Duchenne myodystrophy (DMD) patients with abnormal GLS < -18% with minimum age of 6 years old.

Exclusion Criteria

• Any patient who refuses to sign an informed consent.
• Contraindication to ACEI: hypersensitivity - renal impairment - bilateral renal artery stenosis - aortic valve stenosis - hyperkalemia - hypotension.
• Reduced ejection fraction below 50%.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Duchenne patients subjected to captopril	Captopril Tablets	-

Primary Outcome Measures

Name	Time	Method
The impaired global longitudinal strain will change in echo in the number of participants with duchenne myodystrophy	6 months	Impaired Global longitudinal strain will be changed in echo after 6 months of treatment with Captopril in patients with duchenne myodystrophy

Trial Locations

Locations (1)

Ain Shams university; 🇪🇬 Cairo, Egypt