The Effects of Nicotine withdrawal on Panic-like Response to Breath Holding: A Placebo-Controlled, Double-Blind, Cross-Over Patch Study - Nicotine and BH

IVERSITA` DEGLI STUDI DI FIRENZE - DIPARTIMENTO DI PSICOLOGIA0 个研究点开始时间: 2010年10月29日最近更新: 2014年3月10日

试验速览

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•- being regular smokers, as defined by smoking at least 10 cigarettes per day for at least one year by self report. - age between 18 and 55 years. - either females and males
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•- past history of psychiatric disorders or a current history of Axis I psychiatric disorders, excluding nicotine dependence, based upon their responses to the Mini International Neuropsychiatric Interview (MINI) (Sheenan et al 1994); - at least one first degree relative with panic disorder will be excluded. Indeed, we know that they may have a higher CO2 vulnerability (van Beek et al. 2000); - unstable medical condition; - a history of respiratory disease; - cognitive-behavior psychotherapy during the study; - use of any regular psycho-active drugs (i.e., antidepressant, regular benzodiazepine or non benzodiazepine anxiolytic medication for 4 weeks, or fluoxetine for 5 weeks before the test); - skin diseases or nicotine skin hypersensitivity; - self-reported pregnancy or lactating; - current suicidality; - limited mental competency; - inability to give written informed consent; - current attempts at smoking cessation or reduction.

发起方

IVERSITA` DEGLI STUDI DI FIRENZE - DIPARTIMENTO DI PSICOLOGIA