Prevention of Alcohol Intolerance
- Conditions
- Alcohol Sensitivity
- Interventions
- Drug: Placebo
- Registration Number
- NCT01845220
- Lead Sponsor
- Johns Hopkins University
- Brief Summary
This study is designed to determine whether Asians who are especially sensitive to alcohol exposure can be protected by boosting their activities of an alcohol disposing enzyme. This will be accomplished by administering broccoli sprouts that are rich in an agent that increases protective enzyme activity. The test system involves applying alcohol patches to the skin and measuring skin redness.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
- 18-70 years old,
- sensitive to alcohol on the skin, Japanese
- recent skin abnormalities /tanning
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Broccoli Sprout Extract Broccoli Sprout Extract Each subject will act as his/her own control and receive both treatment and placebo on adjacent skin regions. Placebo Placebo Each subject will act as his/her own control and receive both treatment and placebo on adjacent skin regions.
- Primary Outcome Measures
Name Time Method Mean Area of Skin Erythema (Skin Redness) mean up to 2 hours For three days in a row, volunteers will receive skin treatments with broccoli sprout extract. On day four, their skin will be measured for a baseline skin color reading. Immediately following this reading, the treated areas of the skin will be challenged with 70 percent alcohol and the redness of the skin will again be measured every 30 minutes for the following two hours for skin color changes. The values were collected every 30 minutes after the alcohol skin challenge for 2 hours and were averaged. Mean and 95% Confidence Interval are reported.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Johns Hopkins University
🇺🇸Baltimore, Maryland, United States