Left Ventricular Dyssynchrony: Rest/Stress 3D Blood-Pool Gated D-SPECT Quantification With a High-Speed Dedicated Cardiac Camera Before CRT

University Hospital, Clermont-Ferrand1 site in 1 country30 target enrollmentAugust 2010

ConditionsLeft Ventricular Dyssynchrony

Overview

Phase: N/A
Intervention: Not specified
Conditions: Left Ventricular Dyssynchrony
Sponsor: University Hospital, Clermont-Ferrand
Enrollment: 30
Locations: 1
Primary Endpoint: Left ventricular phase standard deviation.
Last Updated: 14 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Cardiac Resynchronization Therapy (CRT) is an established treatment for patients with advanced heart failure and left ventricular dyssynchrony (LVD). Too many patients do not clinically improve with CRT. New LVD markers other than QRS duration are needed.

Study objective : feasibility assessment of rest and real-time stress 3D Blood-Pool Gated SPECT (BPGS) with a new designed cardiac imaging camera (DSPECT, Spectrum Dynamics®, Ceasaria, Israel) to quantify LVD.

Detailed Description

Sequential 5 min Gated blood pool D-SPECT acquisition at rest and during last stage of dobutamine and atropin infusion (\>85% PHR). Rest and stress left ventricular ejection fraction, phase standard deviation and entropy will be determined using a fully automatic commercial software (QBS, Cedars-Sinai, Los Angeles, CA).

Registry

clinicaltrials.gov

Start Date

August 2010

End Date

October 2011

Last Updated

14 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

University Hospital, Clermont-Ferrand

Eligibility Criteria

Inclusion Criteria

•Chronic heart failure with LVEF \< 35 %, QRS \> 120 ms, NYHA III/IV, optimal medical therapy for more than one month.
•Patient with stable hemodynamic for more than one month,
•More than 18-year old man or woman,
•Patient having given his free, inform and signed consent,
•Patient place setting by the social security system,