NL-OMON34655已完成不适用
Effects of 8 weeks lower-limb resistance training or lower-limb neuromuscular electrical stimulation (NMES) in severely dyspnoeic patients with chronic obstructive pulmonary disease (COPD) with lower-limb muscle dysfunction: a prospective single-blindrandomized controlled trial. - Effects of lower-limb resistance training or lower-limb NMES in COPD.
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Patients with a primary diagnosis of COPD according to the Global Initiative For Chronic Obstructive Pulmonary Lung Disease (GOLD) definition: Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease with some significant extrapulmonary effects that may contribute to the severity in individual patients. Its pulmonary component is characterized by airflow limitation that is not fully reversible.The airflow limitation is usually progressive and associated with an abnormal inflammatory response of the lung to noxious particles or gases. COPD is diagnosed by a chest physician.
- •Medical Research Council dyspnea scale (MRC) 4/5. COPD patients with grade 4 or 5 on the Medical Research Council (MRC) dyspnoea scale (*stops for breath after walking about 100 yards or after a few minutes on level ground* or *too breathless to leave the house, or too breathless when dressing or undressing*, respectively) have been shown to have a higher risk of having quadriceps weakness compared to COPD patients with lower MRC dyspnoea grades, even after correction for the degree of airflow limitation. Almost 50% of the patients with MRC dyspnoea grade 4 or 5 has quadriceps weakness. Moreover, exercise intolerance and reduced health status have been related to higher MRC dyspnoea grades in patients with COPD.
- •Muscle weakness of the lower limbs. Muscle strength and endurance will be measured with the Biodex.
- •Informed consent for voluntary participation.
- •To be able to communicate in the Dutch language.
排除标准
- •Neuromuscular disorders. In neuromuscular disorders a (partial) paralysis will have consequences for the conductance speed of the nerves. The parameters of the treatment by NMES, which are mentioned in the research-protocol, can differ from the parameters which are necessary at neuromuscular disorders
- •Joint disorders in hip, leg and/or knee. Probably these disorders need a different kind of therapy (for example water therapy). Thereby these disorders can ensure confounders in the measurements which to take place in the assessment.
- •Metal implants in hip, leg and/or knee. Metal implants cause a disruption of the electric field. The field lines concentrate on metal. As a consequence overheating and damaging of the tissues around the metal can take place.
- •Cardiac pacemaker or Internal Cardiac Defibrillator (ICD). Although the presence of safety studies patients with implantated pacemakers and ICDs will be excluded.
- •Lack of motivation to participate voluntarily in this study.
- •Patiënten with chronic oxygen suppletion will be xcluded for the measurements with the Oxycon Mobile.
研究者
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