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临床试验/CTRI/2025/07/090539
CTRI/2025/07/090539
尚未招募
不适用

Profiling the clinico-epidemiological, genomic, and immunological markers of dengue and Zika infections and co-infections in Kerala, India via longitudinal studies

Wellcome Trust1 个研究点 分布在 1 个国家目标入组 28,000 人开始时间: 2026年1月1日最近更新:

概览

阶段
不适用
状态
尚未招募
入组人数
28,000
试验地点
1
主要终点
immune correlates of primary and secondary dengue and zika infections and co-infections

概览

简要总结

Probable cases as defined by the WHO 2019 case definition will be recruited for the study to assess clinical manifestations with a particular focus on co infections. Since this is a hospital based study  recruitment will be conducted from the outpatient department of a primary health centre. Eligible patients will be approached and those providing written informed consent will be enrolled. Recruitment will continue until the required sample size is achieved.

研究设计

研究类型
Observational

入排标准

年龄范围
1.00 Day(s) 至 80.00 Year(s)(—)
性别
All

入选标准

  • Patients meeting the WHO probable dengue case definition 2009 or the WHO suspected Zika case definition 2016 with symptom onset including fever within the past five days.
  • Patients willing to provide informed consent to participate in the study.

排除标准

  • Patients who is not willing to give informed written consent.

结局指标

主要结局

immune correlates of primary and secondary dengue and zika infections and co-infections

时间窗: Day 1, 3 and 28 of onset of illness

次要结局

  • dengue & zika burden, clinical features, severity pattern, maternal & neonatal outcomes, genomics of virus, Aedes mosquito bionomics & infection(patients will be followed up on 3rd & 28th day of illness to assess the clinical outcomes. Vector studies will be done every month to capture seasonal variations)

研究者

申办方类型
Other [Biomedical research funding agency]
责任方
Principal Investigator
主要研究者

Dr Manju Rahi

Indian Council of Medical Research Vector Control Research Centre

研究点 (1)

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