Pathophysiology of therapeutic and cognitive side-effects of Electroconvulsive Therapy (ECT).

• Conditions: Depression; depressive disorder; 10027946

• Registration Number: NL-OMON30867
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

- Males and females above 18 years of age
- Unipolar major depressive disorder with and without psychotic features, first and recurrent episode

Exclusion Criteria

- Presence of a current or past relevant somatic or neurological disorder
- Comorbid diagnosis of bipolar depression, schizophrenia or substance dependence.
- MRI-related exclusion criteria like claustrophobia, metal in body, pacemaker, pregnancy, etc.
- ECT course within the past year
- Use of antidepressants (according to good clinical practice, antidepressants have to be withdrawn before an ECT course, so this will not be a major issue).

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Mood (categorical DSM-IV diagnose, severity assessed with observer rated<br /><br>questionaire)<br /><br>- A detail neuropsychological examination (focus on memory and executive<br /><br>functioning).<br /><br>- Neuroimaging, i.e. functional connectivity (fMRI), structural connectivity<br /><br>(DTI), and amygdale reactivity (fMRI: Hariri paradigm)<br /><br>- Hypothalamic-pituitary-adrenal axis functioning (dexamethason suppression<br /><br>test) by nine cortisol measures in saliva. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>N.A.</p><br>