Reproductive Outcome of EM Treated by GnRH-a Associated With Laparoscopy
Not Applicable
- Conditions
- Infertility Associated With Endometriosis
- Interventions
- Registration Number
- NCT02779387
- Lead Sponsor
- Peking University People's Hospital
- Brief Summary
This study is a multicenter, randomized-control-trial. This study select 1184 Infertile patients associated with endometriosis diagnosed by laparoscopy surgery. Patients are going to be divided into two groups according to 1:1 ratio randomly assigned to receive GnRH-a. Cumulative pregnancy rate, end of treatment to natural pregnancy time, accept the assisted reproductive treatment rate, miscarriage rate, live birth rate will be recorded.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 1184
Inclusion Criteria
- Infertile patients
- Endometriosis I-II phase：according to Revised American Society for Reproductive Medicine classification of endometriosis: 1996
- BMI:19-28 kg/㎡
- Ovarian reserve function is normal（M2-5：bilateral antral follicles≥6 FSH：5-12U/ml）
Exclusion Criteria
- Male factor causes infertility
- hydrosalpinx or salpingemphraxis
- Uterine malformation
- Uterine cavity lesion
- Contra-indications for GnRH-a
- not willing to participate
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description GnRH-a Goserelin Acetate patients treated with GnRH-a after surgery and Outpatient guidance .
- Primary Outcome Measures
Name Time Method Time interval between surgery and natural pregnancy 18 month after surgery Time interval between surgery and natural pregnancy
Cumulative pregnancy rate 18 month after surgery Cumulative pregnancy rate of 18 month after surgery
miscarriage rate 18 month after surgery miscarriage rate of patients who get natural pregnancy
- Secondary Outcome Measures
Name Time Method