A clinical trial to predict non invasive ventilation failure in chronic obstructive pulmonary disease patients using ultrasonographic evaluation of diaphragm

Recruiting

Conditions: Chronic obstructive pulmonary disease with (acute) exacerbation,

Registration Number: CTRI/2023/03/050196

Lead Sponsor: Dr Kanika Chaudhary

Brief Summary: Non-Invasive Ventilation (NIV) failure rates are increasing nowadays in patients admitted with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Sonographic assessment of the diaphragm is a non-invasive method of estimating diaphragmatic excursion (DE), speed of contraction (DC), and diaphragmatic thickness fraction (DTF). With these parameters, we can predict NIV failure and prevent delayed endotracheal intubation but there are limited data summarizing their accuracy across multiple studies. We will be performing a prospective observational study to evaluate the diaphragm using the ultrasonographic measurement of DE, DC, and DTF to predict NIV failure in COPD patients

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: All

Target Recruitment: 90

Inclusion Criteria

COPD patients of either gender having a respiratory rate> 30 breaths per minute, peripheral oxygen saturation (SpO2) <88% with oxygen therapy through a Venturi mask or Non-Rebreathing Mask and active use of accessory muscles of respiration or paradoxical abdominal breathing.

Exclusion Criteria

1)Refusal of written informed consent 2)Mentally Retarded patients 3)Shock requiring vasopressors support 4)Acute pulmonary edema 5)Interstitial lung disease 6)Chest wall deformities 7)Previous diaphragmatic palsy 8)Papilledema 9)Pregnancy 10)Obesity (BMI>35 Kg/m2).

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To predict NIV failure	Assessment will be done at baseline,6,12 and 24 hours of NIV treatment

Secondary Outcome Measures

Name	Time	Method
ICU stay, hospital stay and in hospital mortality

Trial Locations

Locations (1): Max Supe specialty Hospital, Dehradun
🇮🇳
Dehradun, UTTARANCHAL, India
Max Supe specialty Hospital, Dehradun
🇮🇳Dehradun, UTTARANCHAL, India
Dr Kanika Chaudhary
Principal investigator
8447992368
kanikaten@gmail.com