Randomized Controlled Trial Evaluating Effect of Furosemide on Confirmation of Ureteral Patency During Routine Cystoscopy
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- time to ureteral patency
研究概览
简要总结
This study evaluates if administration of IV furosemide leads to expedited confirmation of ureteral patency when compared to placebo (IV saline) in routine cystoscopy performed after urogynecologic surgery.
详细描述
Cystoscopy is performed routinely after urogynecologic surgery to ensure there was no injury to the urinary tract (urethra, bladder, or ureters). In order to confirm that no damage occurred to the ureters, a jet of urine must be visualized from each ureteral opening.
The time it takes to confirm this ureteral patency is variable and some sources suggest using furosemide to decrease the time it takes to see these jets. This study will evaluate what effect, if any, this medicine has on time to confirming ureteral patency.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Undergoing any urogynecologic surgery
- •No allergy or contraindication to receiving furosemide
- •Normal Creatinine/glomerular filtration rate
排除标准
- •Unable to consent, including if non English speaking
- •Allergy or contraindication to receiving furosemide
- •Intraoperative injury to the lower urinary tract
研究组 & 干预措施
furosemide
furosemide 10mg (1mL) IV push for one dose
干预措施: furosemide (Drug)
placebo
normal saline 1mL IV push for one dose
干预措施: Normal Saline (Drug)
结局指标
主要结局
time to ureteral patency
时间窗: intra-operative
time to confirmation of ureteral patency in seconds
次要结局
- adverse effects from furosemide administration(immediately post operative (1-3 days post operatively))