Epicatechin - a phytochemical for cardiovascular protection?
Not Applicable
- Conditions
- I10.00
- Registration Number
- DRKS00009846
- Lead Sponsor
- Hochschule Niederrhein
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 48
Inclusion Criteria
Age: 18-65 years; non-smokers; increased cardiovascular risk: overweight or obesity (BMI = 25 kg/m2); blood pressure =130/85 mmHg without medical treatment; slightly increased blood glucose or triglycerides or cholesterol; written informed consent for participation
Exclusion Criteria
Intake of statines, oral antidiabetics or antihypertensiva, intended weight reduction, supplementation of vitamin C, E, beta-carotene aswell as polyphenolrich extracts e.g., from green tea cocoa, red wine, cranberries. Participation in another study/clinical trial simultaneously or within the last 30 days. Known pregnancy or lactation.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical blood pressure (systolic/diastolic), determined after an overnight fast. Measured before and after every intervention. That menas: blood pressure was measured before and after the administration of placebo and active compound
- Secondary Outcome Measures
Name Time Method Vascular elasticity (sonography), blood lipids, carbohydrate metabolism (glucose, insulin), oxidized LDL (ELISA), vitamin C, E, beta-carotene (HPLC), arginine (MS), (-)-epicatechin (HPLC).<br>Measured before and after every intervention (active compund and placebo)