Changes in Echogenicity and Muscle Stiffness in Elastography After Botulinum Toxin Injection a Spastic Muscle - A Monocentric Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Stroke
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
- Enrollment
- 6
- Locations
- 1
- Primary Endpoint
- Change in muscular trophism
- Status
- Terminated
- Last Updated
- 9 years ago
Overview
Brief Summary
Muscle alterations and modifications passive biomechanical properties that occur on a spastic muscle contribute to functional disorders involved in spasticity. Botulinum toxin (TB) A is the reference treatment of the focused spasticity, and muscle source structural and biomechanical changes, very little studied in humans, especially since it is not one possibility of easily and reliably paraclinical assessment injections consequences.
Investigators
Eligibility Criteria
Inclusion Criteria
- •A first stroke older than nine months (acute phase and subacute stroke).
- •Hemiplegia cerebral vascular following this stroke.
- •Hemiplegia with an overall motor deficit plegic lower limb muscle testing level less than or equal to 3 and associating a localized spasticity lower plegic member, on the plantar flexors, assessed by the upper Ashworth Scale or equal to 1 with an injection of botulinum toxin indication of the sural triceps.
- •written consent.
Exclusion Criteria
- •Old stroke with motor impairment of the lower limb in the chronic stage.
- •Concomitant muscle disease (eg myopathy, myositis ...).
- •Patients who already received a botulinum toxin injection into the gastrocnemius muscles.
- •Subjects with defibrillator
Outcomes
Primary Outcomes
Change in muscular trophism
Time Frame: from baseline to 1 year
Change in muscular trophism treated by botulinum toxin. Muscular trophism determined by a combined endpoint assessment of muscular echogenicity following scale Heckmatt I to IV, the measurement of the thickness in mm and angle pennation fascicular of medial and lateral gastrocnemius muscles to measured with an ultrasound scanner