Indicators of Gum Diseases

Recruiting

• Conditions: Measurement and Monitoring,

• Registration Number: CTRI/2018/11/016360
• Lead Sponsor: Rajiv Gandhi University of Health Sciences Karnataka

Brief Summary

study aims to investigate the level of local free haem in GCF at periodontally healthy sites compared with diseased sites in relation to clinical parameters and also to determine any correlation between smoking and haem concentrations at healthy and diseased sites. From a total of 74 subjects  GCF and subgingival plaque samples  will be collected from healthy and diseased sites in both smokers and non-smokers.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-07-05
• Last Update Posted: 2018-11-13

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: All
• Target Recruitment: 74

Inclusion Criteria

• Systemically healthy individuals aged between 20-50 years 2.
• Subjects with at least 20 teeth and 2 non-adjacent probing pocket depth ≥ 5mm and CAL ≥ 3mm per quadrant with radiographic bone loss >20%.

Exclusion Criteria

• Medically compromised patients or any systemic illness which can influence the haemoglobin level of the subject.
• Pregnant/lactating women 3.
• Subjects who have taken antibiotics before the initiation of study 4.
• Subjects with a history of periodontal treatment in the last 6 months 5.
• Subjects with symptoms of acute illness, orthodontic appliances or presence of oral mucosal inflammatory conditions or salivary gland dysfunction.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Initiation and progression of periodontal diseases is the result of a complex interaction between the bacteria colonizing the gingival crevice and the innate and inflammatory responses of the host.this study aims to closely investigate the relationship between GCF free haem concentration, subgingival microbial composition and periodontal clinical parameters in smokers and non-smokers and find out if GCF free haem could be used as a biomarker for periodontal diseases.	3 months

Secondary Outcome Measures

Name	Time	Method
This will help us in identifying susceptible patients in large populations very easily and quickly as it is a chair side diagnostic test. It will also help us to identify active diseased sites, predict sites vulnerable for future breakdown and serve as surrogate end points for monitoring the effectiveness of therapy which may not be possible with conventional diagnostic aids	2 points

Trial Locations

Locations (1)

The Oxford dental college and hospital, Bangalore.; 🇮🇳 Bangalore, KARNATAKA, India

The Oxford dental college and hospital, Bangalore.

🇮🇳Bangalore, KARNATAKA, India

Dr Shobha Krishna Subbaiah

Principal investigator

09743414604

shobhasubbaiah@gmail.com